1s5h

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[[Image:1s5h.png|left|200px]]
 
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==Potassium Channel Kcsa-Fab Complex T75C mutant in K+==
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The line below this paragraph, containing "STRUCTURE_1s5h", creates the "Structure Box" on the page.
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<StructureSection load='1s5h' size='340' side='right'caption='[[1s5h]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s5h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus], [https://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S5H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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{{STRUCTURE_1s5h| PDB=1s5h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5h OCA], [https://pdbe.org/1s5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s5h RCSB], [https://www.ebi.ac.uk/pdbsum/1s5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s5h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCSA_STRCO KCSA_STRCO] Acts as a potassium ion channel (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s5/1s5h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s5h ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The selectivity filter of K(+) channels is comprised of a linear queue of four equal-spaced ion-binding sites spanning a distance of 12A. Each site is formed of eight oxygen atoms from the protein. The first three sites, numbered 1-3 from the extracellular side, are made of exclusively main-chain carbonyl oxygen atoms. The fourth site, closest to the intracellular side, is made of four main-chain carbonyl oxygen atoms and four threonine side-chain hydroxyl oxygen atoms. Here we characterize the effects of mutating the threonine to cysteine on the distribution of ions in the selectivity filter and on the conduction of ions through the filter. The mutation influences the occupancy of K(+) at sites 2 and 4 and it reduces the maximum rate of conduction in the limit of high K(+) concentration. The mutation does not affect the conduction of Rb(+). These results can be understood in the context of a conduction mechanism in which a pair of K ions switch between energetically balanced 1,3 and 2,4 configurations.
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===Potassium Channel Kcsa-Fab Complex T75C mutant in K+===
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A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution.,Zhou M, MacKinnon R J Mol Biol. 2004 May 7;338(4):839-46. PMID:15099749<ref>PMID:15099749</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15099749}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1s5h" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15099749 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15099749}}
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==About this Structure==
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[[1s5h]] is a 3 chain structure of [[Monoclonal Antibody]] and [[Potassium Channel]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_coelicolor,_streptomyces_lividans Streptomyces coelicolor, streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5H OCA].
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==See Also==
==See Also==
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*[[Monoclonal Antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:015099749</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Streptomyces coelicolor, streptomyces lividans]]
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[[Category: Streptomyces coelicolor]]
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[[Category: Mackinnon, R.]]
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[[Category: Streptomyces lividans]]
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[[Category: Zhou, M.]]
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[[Category: Mackinnon R]]
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[[Category: Ion occupancy]]
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[[Category: Zhou M]]
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[[Category: K+ channel]]
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[[Category: Membrane protein]]
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[[Category: Protein-antibody fab complex]]
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[[Category: Selectivity filter]]
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Current revision

Potassium Channel Kcsa-Fab Complex T75C mutant in K+

PDB ID 1s5h

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