This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3uj4
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3uj4 is ON HOLD Authors: Ikura, M., Seo, M.D., Ishiyama, N., Stathopulos, P. Description: Crystal structure of the apo-inositol 1,4,5-trisphosphate...) |
|||
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the apo-inositol 1,4,5-trisphosphate receptor== | |
| + | <StructureSection load='3uj4' size='340' side='right'caption='[[3uj4]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3uj4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UJ4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uj4 OCA], [https://pdbe.org/3uj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uj4 RCSB], [https://www.ebi.ac.uk/pdbsum/3uj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uj4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Ikura M]] | ||
| + | [[Category: Ishiyama N]] | ||
| + | [[Category: Seo MD]] | ||
| + | [[Category: Stathopulos P]] | ||
Current revision
Crystal structure of the apo-inositol 1,4,5-trisphosphate receptor
| |||||||||||
