3u0v

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[[Image:3u0v.jpg|left|200px]]
 
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==Crystal Structure Analysis of human LYPLAL1==
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The line below this paragraph, containing "STRUCTURE_3u0v", creates the "Structure Box" on the page.
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<StructureSection load='3u0v' size='340' side='right'caption='[[3u0v]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3u0v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0v OCA], [https://pdbe.org/3u0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0v RCSB], [https://www.ebi.ac.uk/pdbsum/3u0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0v ProSAT]</span></td></tr>
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{{STRUCTURE_3u0v| PDB=3u0v | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LYPL1_HUMAN LYPL1_HUMAN] Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.<ref>PMID:22052940</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sequence homology indicates the existence of three human cytosolic acyl protein thioesterases, including APT1 that is known to depalmitoylate H- and N-Ras. The lysophospholipase-like 1 (LYPLAL1) protein is predicted to be related to APT1 and might also function as a potential triacylglycerol lipase involved in obesity. However, its role remained unclear. The 1.7 A crystal structure of LYPLAL1 reveals a fold very similar to APT1, but features a shape of the active site that precludes binding of long-chain substrates. Biochemical data demonstrate that LYPLAL1 exhibits neither phospholipase nor triacylglycerol lipase activity, but rather accepts short-chain substrates. Furthermore, extensive screening efforts using chemical array technique revealed a first small molecule inhibitor of LYPLAL1.
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===Crystal Structure Analysis of human LYPLAL1===
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Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity in spite of close relationship to acyl protein thioesterases.,Burger M, Zimmermann TJ, Kondoh Y, Stege P, Watanabe N, Osada H, Waldmann H, Vetter IR J Lipid Res. 2011 Nov 3. PMID:22052940<ref>PMID:22052940</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22052940}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3u0v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22052940 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22052940}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3u0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0V OCA].
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==Reference==
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<ref group="xtra">PMID:022052940</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Burger, M.]]
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[[Category: Large Structures]]
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[[Category: Kondoh, Y.]]
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[[Category: Burger M]]
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[[Category: Osada, H.]]
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[[Category: Kondoh Y]]
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[[Category: Stege, P.]]
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[[Category: Osada H]]
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[[Category: Vetter, I R.]]
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[[Category: Stege P]]
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[[Category: Waldmann, H.]]
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[[Category: Vetter IR]]
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[[Category: Watanabe, N.]]
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[[Category: Waldmann H]]
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[[Category: Zimmermann, T J.]]
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[[Category: Watanabe N]]
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[[Category: Alpha]]
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[[Category: Zimmermann TJ]]
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[[Category: Beta hydrolase fold]]
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[[Category: Hydrolase]]
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Current revision

Crystal Structure Analysis of human LYPLAL1

PDB ID 3u0v

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