4a0i

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[[Image:4a0i.png|left|200px]]
 
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==Crystal structure of Survivin bound to the N-terminal tail of hSgo1==
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The line below this paragraph, containing "STRUCTURE_4a0i", creates the "Structure Box" on the page.
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<StructureSection load='4a0i' size='340' side='right'caption='[[4a0i]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4a0i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.605&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_4a0i| PDB=4a0i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0i OCA], [https://pdbe.org/4a0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0i RCSB], [https://www.ebi.ac.uk/pdbsum/4a0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BIRC5_HUMAN BIRC5_HUMAN] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform.<ref>PMID:10626797</ref> <ref>PMID:9859993</ref> <ref>PMID:12773388</ref> <ref>PMID:16322459</ref> <ref>PMID:16291752</ref> <ref>PMID:18591255</ref> <ref>PMID:20826784</ref> <ref>PMID:21536684</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Localization of the chromosomal passenger complex (CPC) at centromeres during early mitosis is essential for accurate chromosome segregation and is dependent on the phosphorylation of histone H3. We report the 2.7 A resolution structure of the CPC subunit Survivin bound to the N-terminal tail of histone H3 carrying the Thr3 phosphorylation mark (Thr3ph). The BIR domain of Survivin recognizes the Ala1-Arg2-Thr3ph-Lys4 sequence, decoding the modification state and the free N terminus of histone H3 by a strategy similar to that used by PHD fingers. The structural analysis permitted the identification of putative Survivin-binding epitopes in other mitotic proteins, including human Shugoshin 1. Using biophysical and structural data, we show that a phospho-mimic N-terminal sequence such as that of hSgo1 (Ala1-Lys2-Glu3-Arg4) contains the specificity determinants to bind Survivin. Our findings suggest that the CPC engages in mutually exclusive interactions with other constituents of the mitotic machinery and a histone mark in chromatin.
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===CRYSTAL STRUCTURE OF SURVIVIN BOUND TO THE N-TERMINAL TAIL OF HSGO1===
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Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex.,Jeyaprakash AA, Basquin C, Jayachandran U, Conti E Structure. 2011 Oct 25. PMID:22032967<ref>PMID:22032967</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4a0i" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22032967}}, adds the Publication Abstract to the page
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*[[Survivin|Survivin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22032967 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22032967}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[4a0i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0I OCA].
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==Reference==
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<ref group="xtra">PMID:022032967</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Basquin, C.]]
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[[Category: Large Structures]]
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[[Category: Conti, E.]]
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[[Category: Basquin C]]
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[[Category: Jayachandran, U.]]
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[[Category: Conti E]]
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[[Category: Jeyaprakash, A A.]]
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[[Category: Jayachandran U]]
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[[Category: Cell cycle]]
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[[Category: Jeyaprakash AA]]
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[[Category: Cell division]]
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[[Category: Centromere]]
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[[Category: Chromatin]]
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[[Category: Chromosomal passenger complex]]
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[[Category: Mitosis]]
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Current revision

Crystal structure of Survivin bound to the N-terminal tail of hSgo1

PDB ID 4a0i

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