4a0j

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[[Image:4a0j.png|left|200px]]
 
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==Crystal structure of Survivin bound to the phosphorylated N-terminal tail of histone H3==
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The line below this paragraph, containing "STRUCTURE_4a0j", creates the "Structure Box" on the page.
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<StructureSection load='4a0j' size='340' side='right'caption='[[4a0j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4a0j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A0J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.803&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_4a0j| PDB=4a0j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a0j OCA], [https://pdbe.org/4a0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a0j RCSB], [https://www.ebi.ac.uk/pdbsum/4a0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a0j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Localization of the chromosomal passenger complex (CPC) at centromeres during early mitosis is essential for accurate chromosome segregation and is dependent on the phosphorylation of histone H3. We report the 2.7 A resolution structure of the CPC subunit Survivin bound to the N-terminal tail of histone H3 carrying the Thr3 phosphorylation mark (Thr3ph). The BIR domain of Survivin recognizes the Ala1-Arg2-Thr3ph-Lys4 sequence, decoding the modification state and the free N terminus of histone H3 by a strategy similar to that used by PHD fingers. The structural analysis permitted the identification of putative Survivin-binding epitopes in other mitotic proteins, including human Shugoshin 1. Using biophysical and structural data, we show that a phospho-mimic N-terminal sequence such as that of hSgo1 (Ala1-Lys2-Glu3-Arg4) contains the specificity determinants to bind Survivin. Our findings suggest that the CPC engages in mutually exclusive interactions with other constituents of the mitotic machinery and a histone mark in chromatin.
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===CRYSTAL STRUCTURE OF SURVIVIN BOUND TO THE PHOSPHORYLATED N-TERMINAL TAIL OF HISTONE H3===
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Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex.,Jeyaprakash AA, Basquin C, Jayachandran U, Conti E Structure. 2011 Oct 25. PMID:22032967<ref>PMID:22032967</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4a0j" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22032967}}, adds the Publication Abstract to the page
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*[[Survivin|Survivin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22032967 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22032967}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[4a0j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A0J OCA].
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==Reference==
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<ref group="xtra">PMID:022032967</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Basquin, C.]]
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[[Category: Large Structures]]
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[[Category: Conti, E.]]
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[[Category: Basquin C]]
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[[Category: Jayachandran, U.]]
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[[Category: Conti E]]
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[[Category: Jeyaprakash, A A.]]
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[[Category: Jayachandran U]]
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[[Category: Cell cycle]]
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[[Category: Jeyaprakash AA]]
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[[Category: Chromatin]]
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[[Category: Chromosomal passenger complex]]
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[[Category: Mitosis]]
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Current revision

Crystal structure of Survivin bound to the phosphorylated N-terminal tail of histone H3

PDB ID 4a0j

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