2ljb

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[[Image:2ljb.png|left|200px]]
 
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==Structure of the influenza AM2-BM2 chimeric channel==
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The line below this paragraph, containing "STRUCTURE_2ljb", creates the "Structure Box" on the page.
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<StructureSection load='2ljb' size='340' side='right'caption='[[2ljb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ljb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_H3N2 Influenza A virus H3N2] and [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Taiwan/70061/2006) Influenza B virus (B/Taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljb OCA], [https://pdbe.org/2ljb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljb RCSB], [https://www.ebi.ac.uk/pdbsum/2ljb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljb ProSAT]</span></td></tr>
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{{STRUCTURE_2ljb| PDB=2ljb | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B4UQM4_9INFB B4UQM4_9INFB] [https://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The M2 channel of influenza A is a target of the adamantane family antiviral drugs. Two different drug-binding sites have been reported: one inside the pore, and the other is a lipid-facing pocket. A previous study showed that a chimera of M2 variants from influenza A and B that contains only the pore-binding site is sensitive to amantadine inhibition, suggesting that the primary site of inhibition is inside the pore. To obtain atomic details of channel-drug interaction, we determined the structures of the chimeric channel with and without rimantadine. Inside the channel and near the N-terminal end, methyl groups of Val27 and Ala30 from four subunits form a hydrophobic pocket around the adamantane, and the drug amino group appears to be in polar contact with the backbone oxygen of Ala30. The structures also reveal differences between the drug-bound and -unbound states of the channel that can explain drug resistance.
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===Structure of the influenza AM2-BM2 chimeric channel===
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Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses.,Pielak RM, Oxenoid K, Chou JJ Structure. 2011 Nov 9;19(11):1655-63. PMID:22078564<ref>PMID:22078564</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ljb" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[2ljb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus,_influenza_b_virus Influenza a virus, influenza b virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJB OCA].
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*[[M2 protein|M2 protein]]
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[[Category: Influenza a virus, influenza b virus]]
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== References ==
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[[Category: Chou, J J.]]
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<references/>
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[[Category: Oxenoid, K.]]
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__TOC__
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[[Category: Pielak, R M.]]
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</StructureSection>
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[[Category: M2 channel]]
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[[Category: Influenza A virus H3N2]]
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[[Category: Transport protein]]
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[[Category: Large Structures]]
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[[Category: Chou JJ]]
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[[Category: Oxenoid K]]
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[[Category: Pielak RM]]

Current revision

Structure of the influenza AM2-BM2 chimeric channel

PDB ID 2ljb

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