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3tu8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the Burkholderia Lethal Factor 1 (BLF1)== | |
| + | <StructureSection load='3tu8' size='340' side='right'caption='[[3tu8]], [[Resolution|resolution]] 1.04Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3tu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pseudomallei"_whitmore_1913 "bacillus pseudomallei" whitmore 1913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TU8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3tua|3tua]]</div></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BPSL1549 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28450 "Bacillus pseudomallei" Whitmore 1913])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tu8 OCA], [https://pdbe.org/3tu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tu8 RCSB], [https://www.ebi.ac.uk/pdbsum/3tu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tu8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1. | ||
| - | + | A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.,Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW Science. 2011 Nov 11;334(6057):821-4. PMID:22076380<ref>PMID:22076380</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3tu8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus pseudomallei whitmore 1913]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Artymiuk, P J]] | ||
| + | [[Category: Baker, P J]] | ||
| + | [[Category: Chang, C T]] | ||
| + | [[Category: Cruz, A]] | ||
| + | [[Category: Hautbergue, G M]] | ||
| + | [[Category: Mahadi, N M]] | ||
| + | [[Category: Mobbs, G W]] | ||
| + | [[Category: Mohamed, R]] | ||
| + | [[Category: Nathan, S]] | ||
| + | [[Category: Partridge, L J]] | ||
| + | [[Category: Raih, M F]] | ||
| + | [[Category: Rice, D W]] | ||
| + | [[Category: Ruzheinikov, S N]] | ||
| + | [[Category: Sedelnikova, S E]] | ||
| + | [[Category: Wilson, S A]] | ||
| + | [[Category: Toxin]] | ||
| + | [[Category: Unknown function]] | ||
Current revision
Crystal Structure of the Burkholderia Lethal Factor 1 (BLF1)
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Categories: Bacillus pseudomallei whitmore 1913 | Large Structures | Artymiuk, P J | Baker, P J | Chang, C T | Cruz, A | Hautbergue, G M | Mahadi, N M | Mobbs, G W | Mohamed, R | Nathan, S | Partridge, L J | Raih, M F | Rice, D W | Ruzheinikov, S N | Sedelnikova, S E | Wilson, S A | Toxin | Unknown function
