3um6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3um6 is ON HOLD Authors: Vanichtanankul, J, Chitnumsub, P, Kamchonwongpaisan, S, Yuthavong, Y Description: Double mutant (A16V+S108T) Plasmodium fa...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Double mutant (A16V+S108T) Plasmodium falciparum DHFR-TS (T9/94) complexed with cycloguanil, NADPH and dUMP== | |
| + | <StructureSection load='3um6' size='340' side='right'caption='[[3um6]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3um6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UM6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3um6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3um6 OCA], [https://pdbe.org/3um6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3um6 RCSB], [https://www.ebi.ac.uk/pdbsum/3um6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3um6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A7UD81_PLAFA A7UD81_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389] | ||
| - | + | ==See Also== | |
| - | + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Plasmodium falciparum]] | ||
| + | [[Category: Chitnumsub P]] | ||
| + | [[Category: Kamchonwongpaisan S]] | ||
| + | [[Category: Vanichtanankul J]] | ||
| + | [[Category: Yuthavong Y]] | ||
Current revision
Double mutant (A16V+S108T) Plasmodium falciparum DHFR-TS (T9/94) complexed with cycloguanil, NADPH and dUMP
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