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3ton

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[[Image:3ton.jpg|left|200px]]
 
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==Crystral Structure of the C-terminal Subunit of Human Maltase-Glucoamylase==
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The line below this paragraph, containing "STRUCTURE_3ton", creates the "Structure Box" on the page.
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<StructureSection load='3ton' size='340' side='right'caption='[[3ton]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ton]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TON FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.953&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ton FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ton OCA], [https://pdbe.org/3ton PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ton RCSB], [https://www.ebi.ac.uk/pdbsum/3ton PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ton ProSAT]</span></td></tr>
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{{STRUCTURE_3ton| PDB=3ton | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MGA_HUMAN MGA_HUMAN] May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human maltase-glucoamylase (MGAM) hydrolyzes linear alpha-1,4-linked oligosaccharide substrates, playing a crucial role in the production of glucose in the human lumen and acting as an efficient drug target for type 2 diabetes and obesity. The amino- and carboxyl-terminal portions of MGAM (MGAM-N and MGAM-C) carry out the same catalytic reaction but have different substrate specificities. In this study, we report crystal structures of MGAM-C alone at a resolution of 3.1 A, and in complex with its inhibitor acarbose at a resolution of 2.9 A. Structural studies, combined with biochemical analysis, revealed that a segment of 21 amino acids in the active site of MGAM-C forms additional sugar subsites (+ 2 and + 3 subsites), accounting for the preference for longer substrates of MAGM-C compared with that of MGAM-N. Moreover, we discovered that a single mutation of Trp1251 to tyrosine in MGAM-C imparts a novel catalytic ability to digest branched alpha-1,6-linked oligosaccharides. These results provide important information for understanding the substrate specificity of alphaglucosidases during the process of terminal starch digestion, and for designing more efficient drugs to control type 2 diabetes or obesity.
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===Crystral Structure of the C-terminal Subunit of Human Maltase-Glucoamylase===
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Structural insight into substrate specificity of human intestinal maltase-glucoamylase.,Ren L, Qin X, Cao X, Wang L, Bai F, Bai G, Shen Y Protein Cell. 2011 Oct;2(10):827-36. Epub 2011 Nov 6. PMID:22058037<ref>PMID:22058037</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ton" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Alpha-glucosidase 3D structures|Alpha-glucosidase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22058037 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22058037}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3ton]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TON OCA].
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==Reference==
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<ref group="xtra">PMID:022058037</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Qin, X H.]]
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[[Category: Large Structures]]
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[[Category: Ren, L M.]]
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[[Category: Qin XH]]
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[[Category: Shen, Y.]]
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[[Category: Ren LM]]
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[[Category: Carbohydrate/sugar binding]]
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[[Category: Shen Y]]
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[[Category: Hydrolase]]
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[[Category: Membrane]]
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Current revision

Crystral Structure of the C-terminal Subunit of Human Maltase-Glucoamylase

PDB ID 3ton

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