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3sn2

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[[Image:3sn2.jpg|left|200px]]
 
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==Crystal structure analysis of iron regulatory protein 1 in complex with transferrin receptor IRE B RNA==
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The line below this paragraph, containing "STRUCTURE_3sn2", creates the "Structure Box" on the page.
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<StructureSection load='3sn2' size='340' side='right'caption='[[3sn2]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sn2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SN2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sn2 OCA], [https://pdbe.org/3sn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sn2 RCSB], [https://www.ebi.ac.uk/pdbsum/3sn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sn2 ProSAT]</span></td></tr>
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{{STRUCTURE_3sn2| PDB=3sn2 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACOHC_RABIT ACOHC_RABIT] Bifunctional iron sensor that switches between 2 activities depending on iron availability (By similarity). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:17185597). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:17185597).[UniProtKB:P21399]<ref>PMID:17185597</ref> Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.[UniProtKB:P21399]
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===Crystal structure analysis of iron regulatory protein 1 in complex with transferrin receptor IRE B RNA===
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==See Also==
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*[[Aconitase 3D structures|Aconitase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 17185597 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_17185597}}
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==About this Structure==
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[[3sn2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN2 OCA].
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==Reference==
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<ref group="xtra">PMID:017185597</ref><references group="xtra"/>
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[[Category: Aconitate hydratase]]
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[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Selezneva, A I.]]
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[[Category: Selezneva AI]]
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[[Category: Volz, K.]]
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[[Category: Volz K]]
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[[Category: Walden, W E.]]
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[[Category: Walden WE]]
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[[Category: Iron sulfur cluster binding]]
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[[Category: Lyase-rna complex]]
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[[Category: Phosphorylation]]
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[[Category: Rna binding]]
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Current revision

Crystal structure analysis of iron regulatory protein 1 in complex with transferrin receptor IRE B RNA

PDB ID 3sn2

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