3t46

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[[Image:3t46.jpg|left|200px]]
 
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==Crystal structure of Staphylococcal Complement Inhibitor D (SCIN-D) at 1.5 Angstrom==
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The line below this paragraph, containing "STRUCTURE_3t46", creates the "Structure Box" on the page.
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<StructureSection load='3t46' size='340' side='right'caption='[[3t46]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t46]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T46 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_3t46| PDB=3t46 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t46 OCA], [https://pdbe.org/3t46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t46 RCSB], [https://www.ebi.ac.uk/pdbsum/3t46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t46 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Staphylococcal Complement Inhibitor D (SCIN-D) at 1.5 Angstrom===
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0H3JPM4_STAAM A0A0H3JPM4_STAAM] Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses.[ARBA:ARBA00025334]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3t46]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T46 OCA].
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[[Category: Large Structures]]
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[[Category: Staphylococcus aureus subsp. aureus]]
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[[Category: Staphylococcus aureus subsp. aureus Mu50]]
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[[Category: Garcia, B L.]]
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[[Category: Garcia BL]]
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[[Category: Geisbrecht, B V.]]
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[[Category: Geisbrecht BV]]
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[[Category: Summers, B J.]]
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[[Category: Summers BJ]]
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[[Category: Immune system]]
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[[Category: Secreted]]
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[[Category: Virulence]]
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Current revision

Crystal structure of Staphylococcal Complement Inhibitor D (SCIN-D) at 1.5 Angstrom

PDB ID 3t46

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OCA

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