3t47

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[[Image:3t47.jpg|left|200px]]
 
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==Crystal Structure of truncated form of Staphylococcal Complement Inhibitor D (SCIN-D) at 1.3 Angstrom==
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The line below this paragraph, containing "STRUCTURE_3t47", creates the "Structure Box" on the page.
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<StructureSection load='3t47' size='340' side='right'caption='[[3t47]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t47]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T47 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.301&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t47 OCA], [https://pdbe.org/3t47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t47 RCSB], [https://www.ebi.ac.uk/pdbsum/3t47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t47 ProSAT]</span></td></tr>
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{{STRUCTURE_3t47| PDB=3t47 | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of truncated form of Staphylococcal Complement Inhibitor D (SCIN-D) at 1.3 Angstrom===
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[https://www.uniprot.org/uniprot/A0A0H3JPM4_STAAM A0A0H3JPM4_STAAM] Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses.[ARBA:ARBA00025334]
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3t47]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus Staphylococcus aureus subsp. aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T47 OCA].
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[[Category: Staphylococcus aureus subsp. aureus Mu50]]
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[[Category: Staphylococcus aureus subsp. aureus]]
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[[Category: Garcia BL]]
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[[Category: Garcia, B L.]]
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[[Category: Geisbrecht BV]]
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[[Category: Geisbrecht, B V.]]
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[[Category: Summers BJ]]
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[[Category: Summers, B J.]]
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[[Category: Immune system]]
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[[Category: Secreted]]
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[[Category: Virulence]]
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Current revision

Crystal Structure of truncated form of Staphylococcal Complement Inhibitor D (SCIN-D) at 1.3 Angstrom

PDB ID 3t47

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OCA

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