User:Erin Elizabeth Sherman/Sandbox 383

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(New page: ==Background== Human dopamine D3 receptor is a protein that encoded by the dopamine receptor gene (DRD3). The DRD3 gene codes for the D3 dopamine receptor that inhibits adenylyl cyclase th...)
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==Background==
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Human dopamine D3 receptor is a protein that encoded by the dopamine receptor gene (DRD3). The DRD3 gene codes for the D3 dopamine receptor that inhibits adenylyl cyclase through inhibitory G-proteins. This receptor is located in the brain, suggesting that the D3 receptor plays a role in cognitive and emotional functions.
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===Ligands===
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Ligands that are associated with dopamine D3 receptor are 3-chloro-5-ethyl-N{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-6-hydroxyl-2-methyloxybenzamide (ETQ on PDB) and maltose (MAL on PDB). ETQ binds to dopamine D3 receptor by Asp 110A and Phe346A. MAL binds by Asp 1020A, Glu 1022A, Glu1011A, and Leu1032A.
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====Disease Involvement====
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Erin Elizabeth Sherman

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