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3i8t

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[[Image:3i8t.png|left|200px]]
 
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==N-terminal CRD1 domain of mouse Galectin-4 in complex with lactose==
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The line below this paragraph, containing "STRUCTURE_3i8t", creates the "Structure Box" on the page.
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<StructureSection load='3i8t' size='340' side='right'caption='[[3i8t]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3i8t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I8T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PRD_900008:alpha-lactose'>PRD_900008</scene></td></tr>
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{{STRUCTURE_3i8t| PDB=3i8t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i8t OCA], [https://pdbe.org/3i8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i8t RCSB], [https://www.ebi.ac.uk/pdbsum/3i8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i8t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEG4_MOUSE LEG4_MOUSE] Galectin that binds lactose and a related range of sugars (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Galectin-4, a member of the tandem-repeat subfamily of galectins, participates in cell-membrane interactions and plays an important role in cell adhesion and modulation of immunity and malignity. The oligosaccharide specificity of the mouse galectin-4 carbohydrate-recognition domains (CRDs) has been reported previously. In this work, the structure and binding properties of the N-terminal domain CRD1 were further investigated and the crystal structure of CRD1 in complex with lactose was determined at 2.1 A resolution. The lactose-binding affinity was characterized by fluorescence measurements and two lactose-binding sites were identified: a high-affinity site with a K(d) value in the micromolar range (K(d1) = 600 +/- 70 microM) and a low-affinity site with K(d2) = 28 +/- 10 mM.
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===N-terminal CRD1 domain of mouse Galectin-4 in complex with lactose===
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Structure of the mouse galectin-4 N-terminal carbohydrate-recognition domain reveals the mechanism of oligosaccharide recognition.,Krejcirikova V, Pachl P, Fabry M, Maly P, Rezacova P, Brynda J Acta Crystallogr D Biol Crystallogr. 2011 Mar;67(Pt 3):204-11. Epub 2011, Feb 15. PMID:21358051<ref>PMID:21358051</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3i8t" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21358051}}, adds the Publication Abstract to the page
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*[[Galectin 3D structures|Galectin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21358051 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21358051}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3i8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I8T OCA].
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==Reference==
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<ref group="xtra">PMID:021358051</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Brynda, J.]]
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[[Category: Brynda J]]
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[[Category: Krejcirikova, V.]]
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[[Category: Krejcirikova V]]
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[[Category: Rezacova, P.]]
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[[Category: Rezacova P]]
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[[Category: Carbohydrate binding]]
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[[Category: Lectin]]
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[[Category: Molecular recognition]]
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[[Category: S-type lectin]]
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[[Category: Sugar binding protein]]
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Current revision

N-terminal CRD1 domain of mouse Galectin-4 in complex with lactose

PDB ID 3i8t

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