2yio

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[[Image:2yio.png|left|200px]]
 
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==Crystal Structure of Parasite Sarcocystis muris Microneme Protein SML- 2 in complex with 1-Thio-beta-D-Galactose (SPACEGROUP C2221)==
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The line below this paragraph, containing "STRUCTURE_2yio", creates the "Structure Box" on the page.
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<StructureSection load='2yio' size='340' side='right'caption='[[2yio]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yio]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YIO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>
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{{STRUCTURE_2yio| PDB=2yio | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yio OCA], [https://pdbe.org/2yio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yio RCSB], [https://www.ebi.ac.uk/pdbsum/2yio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yio ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MIA2_SARMU MIA2_SARMU] Galactose-binding lectin. Plays a role in adhesion to the host cell. Has a potential role in invasion of host cells.<ref>PMID:12743810</ref> <ref>PMID:22101820</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The microneme protein SML-2 is a member of a small family of galactose-specific lectins that play a role during host-cell invasion by the apicomplexan parasite Sarcocystis muris. The structures of apo SML-2 and the 1-thio-beta-D-galactose-SML-2 complex were determined at 1.95 and 2.1 A resolution, respectively, by sulfur-SAD phasing. Highly elongated dimers are formed by PAN-domain tandems in the protomer, bearing the galactose-binding cavities at the distal apple-like domains. The detailed structure of the binding site in SML-2 explains the high specificity of galactose-endgroup binding and the broader specificity of the related Toxoplasma gondii protein TgMIC4 towards galactose and glucose. A large buried surface of highly hydrophobic character and 24 intersubunit hydrogen bonds stabilize the dimers and half of the 12 disulfides per dimer are shielded from the solvent by the polypeptide chain, thereby enhancing the resistance of the parasite protein towards unfolding and proteolysis that allows it to survive within the intestinal tracts of the intermediate and final hosts.
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===CRYSTAL STRUCTURE OF PARASITE SARCOCYSTIS MURIS MICRONEME PROTEIN SML-2 IN COMPLEX WITH 1-THIO-BETA-D-GALACTOSE (SPACEGROUP C2221).===
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PAN-modular structure of microneme protein SML-2 from the parasite Sarcocystis muris at 1.95 A resolution and its complex with 1-thio-beta-D-galactose.,Muller JJ, Weiss MS, Heinemann U Acta Crystallogr D Biol Crystallogr. 2011 Nov;67(Pt 11):936-44. Epub 2011, Oct 19. PMID:22101820<ref>PMID:22101820</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22101820}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2yio" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22101820 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22101820}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2yio]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sarcocystis_muris Sarcocystis muris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YIO OCA].
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==Reference==
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<ref group="xtra">PMID:022101820</ref><references group="xtra"/>
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[[Category: Sarcocystis muris]]
[[Category: Sarcocystis muris]]
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[[Category: Heinemann, U.]]
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[[Category: Heinemann U]]
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[[Category: Mueller, J J.]]
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[[Category: Mueller JJ]]
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[[Category: Apple-domain tandem repeat]]
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[[Category: Cellular adhesion]]
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[[Category: Galactose-binding lectin]]
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[[Category: Micronemal protein]]
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[[Category: Pan_1]]
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[[Category: Pan_ap]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal Structure of Parasite Sarcocystis muris Microneme Protein SML- 2 in complex with 1-Thio-beta-D-Galactose (SPACEGROUP C2221)

PDB ID 2yio

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