3ara

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[[Image:3ara.png|left|200px]]
 
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==Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors==
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The line below this paragraph, containing "STRUCTURE_3ara", creates the "Structure Box" on the page.
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<StructureSection load='3ara' size='340' side='right'caption='[[3ara]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ara]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ARA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MKH:1-[3-({(2R)-2-[HYDROXY(DIPHENYL)METHYL]PYRROLIDIN-1-YL}SULFONYL)PROPYL]PYRIMIDINE-2,4(1H,3H)-DIONE'>MKH</scene></td></tr>
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{{STRUCTURE_3ara| PDB=3ara | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ara FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ara OCA], [https://pdbe.org/3ara PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ara RCSB], [https://www.ebi.ac.uk/pdbsum/3ara PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ara ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref>
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===Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors===
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==See Also==
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*[[DUTPase 3D structures|DUTPase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3ara]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ARA OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: DUTP diphosphatase]]
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[[Category: Large Structures]]
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[[Category: Chong, K T.]]
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[[Category: Chong KT]]
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[[Category: Fukuoka, M.]]
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[[Category: Fukuoka M]]
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[[Category: Miyahara, S.]]
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[[Category: Miyahara S]]
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[[Category: Miyakoshi, H.]]
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[[Category: Miyakoshi H]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Magnesium binding]]
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Current revision

Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors

PDB ID 3ara

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