2lm1

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'''Unreleased structure'''
 
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The entry 2lm1 is ON HOLD
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==Solution NMR Structure of Lysine-specific demethylase lid from Drosophila melanogaster, Northeast Structural Genomics Consortium Target FR824D==
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<StructureSection load='2lm1' size='340' side='right'caption='[[2lm1]]' scene=''>
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Authors: Mills, J.L., Lee, D., Kohan, E., Sahdev, S., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lm1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LM1 FirstGlance]. <br>
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Description: Solution NMR Structure of Lysine-specific demethylase lid from Drosophila melanogaster, Northeast Structural Genomics Consortium Target FR824D
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lm1 OCA], [https://pdbe.org/2lm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lm1 RCSB], [https://www.ebi.ac.uk/pdbsum/2lm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lm1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM5_DROME KDM5_DROME] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development.<ref>PMID:11014813</ref> <ref>PMID:17311883</ref> <ref>PMID:17351631</ref> <ref>PMID:17351630</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Drosophila melanogaster]]
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[[Category: Large Structures]]
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[[Category: Acton TB]]
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[[Category: Everett JK]]
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[[Category: Kohan E]]
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[[Category: Kusch T]]
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[[Category: Lee D]]
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[[Category: Mills JL]]
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[[Category: Montelione GT]]
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[[Category: Sahdev S]]
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[[Category: Szyperski T]]
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[[Category: Xiao R]]

Current revision

Solution NMR Structure of Lysine-specific demethylase lid from Drosophila melanogaster, Northeast Structural Genomics Consortium Target FR824D

PDB ID 2lm1

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