3ur6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3ur6 is ON HOLD Authors: Lovell, S., Battaile, K.P., Kim, Y., Tiew, K.C., Mandadapu, S.R., Alliston, K.R., Groutas, W.C., Chang, K.O. Description: ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==1.5A resolution structure of apo Norwalk Virus Protease== | |
| + | <StructureSection load='3ur6' size='340' side='right'caption='[[3ur6]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ur6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_Hu/1968/US Norovirus Hu/1968/US]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UR6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ur6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ur6 OCA], [https://pdbe.org/3ur6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ur6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ur6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ur6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/POLG_NVN68 POLG_NVN68] Protein p48 may play a role in viral replication by interacting with host VAPA, a vesicle-associated membrane protein that plays a role in SNARE-mediated vesicle fusion. This interaction may target replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Protein P22 may play a role in targeting replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref> RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Virus protease 3D structures|Virus protease 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Norovirus Hu/1968/US]] | ||
| + | [[Category: Alliston KR]] | ||
| + | [[Category: Battaile KP]] | ||
| + | [[Category: Chang KO]] | ||
| + | [[Category: Groutas WC]] | ||
| + | [[Category: Kim Y]] | ||
| + | [[Category: Lovell S]] | ||
| + | [[Category: Mandadapu SR]] | ||
| + | [[Category: Tiew KC]] | ||
Current revision
1.5A resolution structure of apo Norwalk Virus Protease
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