3urn
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3urn is ON HOLD Authors: Tsai, P., Fox, N.G., Li, Y., Barondeau, D.P., Raushel, F.M. Description: Crystal Structure of PTE mutant H254G/H257W/L303T...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of PTE mutant H254G/H257W/L303T/K185R/I274N/A80V/S61T with cyclohexyl methylphosphonate inhibitor== | |
| + | <StructureSection load='3urn' size='340' side='right'caption='[[3urn]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3urn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevundimonas_diminuta Brevundimonas diminuta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3URN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3URN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=QMP:CYCLOHEXYL+METHYLPHOSPHONATE'>QMP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3urn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3urn OCA], [https://pdbe.org/3urn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3urn RCSB], [https://www.ebi.ac.uk/pdbsum/3urn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3urn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OPD_BREDI OPD_BREDI] Has an unusual substrate specificity for synthetic organophosphate triesters and phosphorofluoridates. All of the phosphate triesters found to be substrates are synthetic compounds. The identity of any naturally occurring substrate for the enzyme is unknown. Has no detectable activity with phosphate monoesters or diesters and no activity as an esterase or protease. It catalyzes the hydrolysis of the insecticide paraoxon at a rate approaching the diffusion limit and thus appears to be optimally evolved for utilizing this synthetic substrate. | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphotriesterase 3D structures|Phosphotriesterase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Brevundimonas diminuta]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Barondeau DP]] | ||
| + | [[Category: Fox NG]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Raushel FM]] | ||
| + | [[Category: Tsai P]] | ||
Current revision
Crystal Structure of PTE mutant H254G/H257W/L303T/K185R/I274N/A80V/S61T with cyclohexyl methylphosphonate inhibitor
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