2lgx

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[[Image:2lgx.jpg|left|200px]]
 
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==NMR structure for Kindle-2 N-terminus==
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The line below this paragraph, containing "STRUCTURE_2lgx", creates the "Structure Box" on the page.
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<StructureSection load='2lgx' size='340' side='right'caption='[[2lgx]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lgx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LGX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lgx OCA], [https://pdbe.org/2lgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lgx RCSB], [https://www.ebi.ac.uk/pdbsum/2lgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lgx ProSAT]</span></td></tr>
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{{STRUCTURE_2lgx| PDB=2lgx | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FERM2_HUMAN FERM2_HUMAN] Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.<ref>PMID:12679033</ref> <ref>PMID:18458155</ref> <ref>PMID:21325030</ref> <ref>PMID:22699938</ref> <ref>PMID:22030399</ref> <ref>PMID:22078565</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Kindlin-2 belongs to an emerging class of regulators for heterodimeric (alpha/beta) integrin adhesion receptors. By binding to integrin beta cytoplasmic tail via its C-terminal FERM-like domain, kindlin-2 promotes integrin activation. Intriguingly, this activation process depends on the N terminus of kindlin-2 (K2-N) that precedes the FERM domain. The molecular function of K2-N is unclear. We present the solution structure of K2-N, which displays a ubiquitin fold similar to that observed in kindlin-1. Using chemical shift mapping and mutagenesis, we found that K2-N contains a conserved positively charged surface that binds to membrane enriched with negatively charged phosphatidylinositol-(4,5)-bisphosphate. We show that while wild-type kindlin-2 is capable of promoting integrin activation, such ability is significantly reduced for its membrane-binding defective mutant. These data suggest a membrane-binding function of the ubiquitin-like domain of kindlin-2, which is likely common for all kindlins to promote their localization to the plasma membrane and control integrin activation.
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===NMR structure for Kindle-2 N-terminus===
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Membrane Binding of the N-Terminal Ubiquitin-Like Domain of kindlin-2 Is Crucial for Its Regulation of Integrin Activation.,Perera HD, Ma YQ, Yang J, Hirbawi J, Plow EF, Qin J Structure. 2011 Nov 9;19(11):1664-71. PMID:22078565<ref>PMID:22078565</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2lgx" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22078565 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22078565}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2lgx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGX OCA].
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==Reference==
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<ref group="xtra">PMID:022078565</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hirbawi, J.]]
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[[Category: Large Structures]]
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[[Category: Ma, Y.]]
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[[Category: Hirbawi J]]
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[[Category: Perera, H D.]]
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[[Category: Ma Y]]
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[[Category: Plow, E F.]]
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[[Category: Perera HD]]
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[[Category: Qin, J.]]
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[[Category: Plow EF]]
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[[Category: Yang, J.]]
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[[Category: Qin J]]
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[[Category: Cell adhesion]]
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[[Category: Yang J]]
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[[Category: Integrin activation]]
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[[Category: Kindlin]]
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[[Category: Membrane]]
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Current revision

NMR structure for Kindle-2 N-terminus

PDB ID 2lgx

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OCA

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