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3zv0

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[[Image:3zv0.jpg|left|200px]]
 
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==Structure of the SHQ1P-CBF5P complex==
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The line below this paragraph, containing "STRUCTURE_3zv0", creates the "Structure Box" on the page.
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<StructureSection load='3zv0' size='340' side='right'caption='[[3zv0]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zv0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZV0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_3zv0| PDB=3zv0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv0 OCA], [https://pdbe.org/3zv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zv0 RCSB], [https://www.ebi.ac.uk/pdbsum/3zv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SHQ1_YEAST SHQ1_YEAST] Involved in the early biogenesis steps of box H/ACA snoRNP assembly.<ref>PMID:12228251</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SHQ1 is an essential assembly factor for H/ACA ribonucleoproteins (RNPs) required for ribosome biogenesis, pre-mRNA splicing, and telomere maintenance. SHQ1 binds dyskerin/NAP57, the catalytic subunit of human H/ACA RNPs, and this interaction is modulated by mutations causing X-linked dyskeratosis congenita. We report the crystal structure of the C-terminal domain of yeast SHQ1, Shq1p, and its complex with yeast dyskerin/NAP57, Cbf5p, lacking its catalytic domain. The C-terminal domain of Shq1p interacts with the RNA-binding domain of Cbf5p and, through structural mimicry, uses the RNA-protein-binding sites to achieve a specific protein-protein interface. We propose that Shq1p operates as a Cbf5p chaperone during RNP assembly by acting as an RNA placeholder, thereby preventing Cbf5p from nonspecific RNA binding before association with an H/ACA RNA and the other core RNP proteins.
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===STRUCTURE OF THE SHQ1P-CBF5P COMPLEX===
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The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic.,Walbott H, Machado-Pinilla R, Liger D, Blaud M, Rety S, Grozdanov PN, Godin K, van Tilbeurgh H, Varani G, Meier UT, Leulliot N Genes Dev. 2011 Nov 15;25(22):2398-408. PMID:22085966<ref>PMID:22085966</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22085966}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3zv0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22085966 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22085966}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3zv0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV0 OCA].
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Blaud M]]
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==Reference==
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[[Category: Godin K]]
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<ref group="xtra">PMID:022085966</ref><references group="xtra"/>
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[[Category: Grozdanov PN]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Leulliot N]]
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[[Category: Blaud, M.]]
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[[Category: Liger D]]
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[[Category: Godin, K.]]
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[[Category: Machado-Pinilla R]]
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[[Category: Grozdanov, P N.]]
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[[Category: Meier UT]]
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[[Category: Leulliot, N.]]
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[[Category: Rety S]]
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[[Category: Liger, D.]]
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[[Category: Varani G]]
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[[Category: Machado-Pinilla, R.]]
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[[Category: Walbott H]]
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[[Category: Meier, U T.]]
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[[Category: VanTilbeurgh H]]
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[[Category: Rety, S.]]
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[[Category: Vantilbeurgh, H.]]
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[[Category: Varani, G.]]
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[[Category: Walbott, H.]]
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[[Category: Cell cycle]]
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[[Category: Rnp assembly]]
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[[Category: Telomerase]]
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[[Category: X-linked dyskeratosis congenita]]
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Current revision

Structure of the SHQ1P-CBF5P complex

PDB ID 3zv0

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