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3svm

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[[Image:3svm.jpg|left|200px]]
 
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==Human MPP8 - human DNMT3AK47me2 peptide==
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The line below this paragraph, containing "STRUCTURE_3svm", creates the "Structure Box" on the page.
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<StructureSection load='3svm' size='340' side='right'caption='[[3svm]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3svm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SVM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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{{STRUCTURE_3svm| PDB=3svm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3svm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3svm OCA], [https://pdbe.org/3svm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3svm RCSB], [https://www.ebi.ac.uk/pdbsum/3svm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3svm ProSAT]</span></td></tr>
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</table>
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===Human MPP8 - human DNMT3AK47me2 peptide===
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== Function ==
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[https://www.uniprot.org/uniprot/MPP8_HUMAN MPP8_HUMAN] Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.<ref>PMID:20871592</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22086334 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22086334}}
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==About this Structure==
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[[3svm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SVM OCA].
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==Reference==
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<ref group="xtra">PMID:022086334</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chang, Y.]]
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[[Category: Large Structures]]
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[[Category: Cheng, X.]]
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[[Category: Chang Y]]
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[[Category: Horton, J R.]]
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[[Category: Cheng X]]
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[[Category: Zhang, X.]]
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[[Category: Horton JR]]
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[[Category: Chromodomain]]
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[[Category: Zhang X]]
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[[Category: Dimethylated lysine]]
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[[Category: Epigenetic]]
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[[Category: Methyl-lysine binding]]
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[[Category: Mpp8 chromodomain]]
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[[Category: The dimethylated human dnmt3ak47me2 is recognized by the chromodomain of mpp8]]
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[[Category: Transferase]]
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Current revision

Human MPP8 - human DNMT3AK47me2 peptide

PDB ID 3svm

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OCA

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