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3zuz

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[[Image:3zuz.jpg|left|200px]]
 
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==Structure of Shq1p C-terminal domain==
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The line below this paragraph, containing "STRUCTURE_3zuz", creates the "Structure Box" on the page.
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<StructureSection load='3zuz' size='340' side='right'caption='[[3zuz]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zuz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZUZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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{{STRUCTURE_3zuz| PDB=3zuz | SCENE= }}
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3zv0|3zv0]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zuz OCA], [https://pdbe.org/3zuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zuz RCSB], [https://www.ebi.ac.uk/pdbsum/3zuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zuz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/SHQ1_YEAST SHQ1_YEAST]] Involved in the early biogenesis steps of box H/ACA snoRNP assembly.<ref>PMID:12228251</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SHQ1 is an essential assembly factor for H/ACA ribonucleoproteins (RNPs) required for ribosome biogenesis, pre-mRNA splicing, and telomere maintenance. SHQ1 binds dyskerin/NAP57, the catalytic subunit of human H/ACA RNPs, and this interaction is modulated by mutations causing X-linked dyskeratosis congenita. We report the crystal structure of the C-terminal domain of yeast SHQ1, Shq1p, and its complex with yeast dyskerin/NAP57, Cbf5p, lacking its catalytic domain. The C-terminal domain of Shq1p interacts with the RNA-binding domain of Cbf5p and, through structural mimicry, uses the RNA-protein-binding sites to achieve a specific protein-protein interface. We propose that Shq1p operates as a Cbf5p chaperone during RNP assembly by acting as an RNA placeholder, thereby preventing Cbf5p from nonspecific RNA binding before association with an H/ACA RNA and the other core RNP proteins.
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===STRUCTURE OF SHQ1P C-TERMINAL DOMAIN===
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The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic.,Walbott H, Machado-Pinilla R, Liger D, Blaud M, Rety S, Grozdanov PN, Godin K, van Tilbeurgh H, Varani G, Meier UT, Leulliot N Genes Dev. 2011 Nov 15;25(22):2398-408. PMID:22085966<ref>PMID:22085966</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22085966}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3zuz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22085966 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22085966}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Baker's yeast]]
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[[3zuz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZUZ OCA].
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[[Category: Large Structures]]
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[[Category: Blaud, M]]
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==Reference==
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[[Category: Godin, K]]
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<ref group="xtra">PMID:022085966</ref><references group="xtra"/>
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[[Category: Grozdanov, P N]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Leulliot, N]]
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[[Category: Blaud, M.]]
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[[Category: Liger, D]]
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[[Category: Godin, K.]]
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[[Category: Machado-Pinilla, R]]
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[[Category: Grozdanov, P N.]]
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[[Category: Meier, U T]]
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[[Category: Leulliot, N.]]
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[[Category: Rety, S]]
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[[Category: Liger, D.]]
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[[Category: Varani, G]]
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[[Category: Machado-Pinilla, R.]]
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[[Category: Walbott, H]]
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[[Category: Meier, U T.]]
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[[Category: VanTilbeurgh, H]]
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[[Category: Rety, S.]]
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[[Category: Vantilbeurgh, H.]]
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[[Category: Varani, G.]]
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[[Category: Walbott, H.]]
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[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Rnp assembly]]
[[Category: Rnp assembly]]
[[Category: Telomerase]]
[[Category: Telomerase]]
[[Category: X-linked dyskeratosis congenita]]
[[Category: X-linked dyskeratosis congenita]]

Current revision

Structure of Shq1p C-terminal domain

PDB ID 3zuz

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