3t0g

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[[Image:3t0g.jpg|left|200px]]
 
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==IspH:HMBPP (substrate) structure of the T167C mutant==
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The line below this paragraph, containing "STRUCTURE_3t0g", creates the "Structure Box" on the page.
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<StructureSection load='3t0g' size='340' side='right'caption='[[3t0g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T0G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=H6P:(2E)-4-HYDROXY-3-METHYLBUT-2-EN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>H6P</scene></td></tr>
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{{STRUCTURE_3t0g| PDB=3t0g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t0g OCA], [https://pdbe.org/3t0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t0g RCSB], [https://www.ebi.ac.uk/pdbsum/3t0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t0g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
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===IspH:HMBPP (substrate) structure of the T167C mutant===
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==See Also==
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*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3t0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T0G OCA].
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__TOC__
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[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Bacher, A.]]
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[[Category: Large Structures]]
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[[Category: Eisenreich, W.]]
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[[Category: Bacher A]]
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[[Category: Graewert, T.]]
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[[Category: Eisenreich W]]
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[[Category: Groll, M.]]
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[[Category: Graewert T]]
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[[Category: Span, I.]]
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[[Category: Groll M]]
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[[Category: 3fe-4s iron-sulfur cluster]]
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[[Category: Span I]]
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[[Category: Conserved cysteine]]
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[[Category: Ipp and dmapp production final step]]
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[[Category: Low activity]]
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[[Category: Non-mevalonate pathway]]
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[[Category: Oxidoreductase]]
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[[Category: Substrate hmbpp]]
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Current revision

IspH:HMBPP (substrate) structure of the T167C mutant

PDB ID 3t0g

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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