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M2 protein

From Proteopedia

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{{STRUCTURE_3c9j| PDB=3c9j | SIZE=400| SCENE= |right| CAPTION=NMR structure of cytoplasmic domain of M2 protein from influenza B virus, [[3c9j]] }}
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<StructureSection load='4c3e' size='350' side='right' caption='Human respiratory syncytial virus M2 protein complex with Zn+2 ions (grey) (PDB entry [[4c3e]])' scene='45/458472/Cv/1'>
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__TOC__
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== Function ==
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The '''M2 protein''' or '''Matrix protein 2''' (M2) is a proton selective ion channel of the influenza virus<ref>PMID:18045172</ref>. It is activated by low pH. M2 has 3 domains: an ectodomain, transmembrane domain (TM) and a C terminal cytoplasmic domain. See more in:<br />
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[[M2 Proton Channel]]<br />
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[[Molecular Playground/Influenza A M2 transmembrane domain]]<br />
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[[M2 Proton Channel Inhibitor Pharmacokinetics]].
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The '''M2 protein''' (M2) is a proton selective ion channelof the infl;uenza virus. It is activated by low pH. M2 has 3 domains: an ectodomain, transmembrane domain (TM) and a C terminal cytoplasmic domain. Transmembrane domain details at [[Molecular Playground/Influenza A M2 transmembrane domain]].
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== Structural highlights ==
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M2 protein from Human respiratory syncytial virus contains 4 domains: Zn-binding, transmembrane (TM), core which binds RNA and a C terminal domain<ref>PMID:24434552</ref>. <scene name='45/458472/Cv/3'>Zn binding site</scene>.
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{{TOC limit|limit=2}}
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==3D structures of M2 protein==
==3D structures of M2 protein==
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''Updated December 2011''
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[3lbw]] – IavM2 TM (mutant) – Influenza A virus<br />
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[[3bkd]], [[5um1]], [[5ttc]], [[5joo]], [[4qkm]], [[4qkl]], [[4qkc]], [[4qk7]], [[6mpl]], [[6mpm]], [[6mpn]] - IavM2 TM – Influenza A virus<br />
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[[3bkd]] - IavM2 TM<br />
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[[3lbw]], [[5c02]], [[4rwc]], [[4rwb]] – IavM2 TM (mutant) <br />
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[[3c9j]] - IavM2 TM + amantadine<br />
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[[3c9j]], [[6bkk]], [[6bmz]] - IavM2 TM + amantadine derivative<br />
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[[2kqt]], [[1mp6]] - IavM2 TM – NMR<br />
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[[6oug]] - IavM2 TM (mutant) + amantadine derivative<br />
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[[6bkl]], [[6boc]] - IavM2 TM + rimantadine<br />
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[[2rlf]] - IavM2 TM +rimantadine - NMR<br />
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[[2kqt]], [[1mp6]], [[1nyj]], [[2h95]] - IavM2 TM – NMR<br />
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[[2kih]], [[2kwx]], [[2l0j]] - IavM2 TM (mutant) – NMR<br />
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[[2ljb]], [[2ljc]] - IavM2 TM (mutant)/IbvM2 TM – NMR<br />
[[2kix]] - IbvM2 TM (mutant) – Influenza B virus – NMR<br />
[[2kix]] - IbvM2 TM (mutant) – Influenza B virus – NMR<br />
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[[2kj1]] – IbvM2 cytoplasmic domain - NMR
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[[2kj1]] – IbvM2 cytoplasmic domain - NMR<br />
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[[4c3b]], [[4c3d]] – hrsvM2 – Human respiratory syncytial virus<br />
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[[4c3e]] – hrsvM2 (mutant)<br />
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[[5nkx]] – hrsvM2 core domain 73-185<br />
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[[2l9j]] – hrsvM2 core domain (mutant) - NMR<br />
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[[6g0y]] – hrsvM2 + phosphoprotein<br />
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[[6pzq]] – hrsvM2 + RNA<br />
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[[5hyu]] – M2 residues 42-142 + C4B-binding protein alpha chain – ''Steptococcus pyogenes''<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human respiratory syncytial virus M2 protein complex with Zn+2 ions (grey) (PDB entry 4c3e)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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