3ttz

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[[Image:3ttz.png|left|200px]]
 
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==Crystal structure of a topoisomerase ATPase inhibitor==
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The line below this paragraph, containing "STRUCTURE_3ttz", creates the "Structure Box" on the page.
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<StructureSection load='3ttz' size='340' side='right'caption='[[3ttz]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ttz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TTZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TTZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=07N:2-[(3S,4R)-4-{[(3,4-DICHLORO-5-METHYL-1H-PYRROL-2-YL)CARBONYL]AMINO}-3-FLUOROPIPERIDIN-1-YL]-1,3-THIAZOLE-5-CARBOXYLIC+ACID'>07N</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u2d|3u2d]], [[3u2k|3u2k]]</div></td></tr>
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{{STRUCTURE_3ttz| PDB=3ttz | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gyrB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ttz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ttz OCA], [https://pdbe.org/3ttz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ttz RCSB], [https://www.ebi.ac.uk/pdbsum/3ttz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ttz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The pyrrolamides are a new class of antibacterial agents targeting DNA gyrase, an essential enzyme across bacterial species and inhibition results in the disruption of DNA synthesis and subsequently, cell death. The optimization of biochemical activity and other drug-like properties through substitutions to the pyrrole, piperidine, and heterocycle portions of the molecule resulted in pyrrolamides with improved cellular activity and in vivo efficacy.
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===Crystal structure of a topoisomerase ATPase inhibitor===
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Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy.,Sherer BA, Hull K, Green O, Basarab G, Hauck S, Hill P, Loch JT 3rd, Mullen G, Bist S, Bryant J, Boriack-Sjodin A, Read J, Degrace N, Uria-Nickelsen M, Illingworth RN, Eakin AE Bioorg Med Chem Lett. 2011 Oct 12. PMID:22041057<ref>PMID:22041057</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ttz" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22041057}}, adds the Publication Abstract to the page
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22041057 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22041057}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3ttz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TTZ OCA].
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[[Category: Boriack-Sjodin, P A]]
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[[Category: Eakin, A E]]
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==Reference==
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[[Category: Read, J]]
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<ref group="xtra">PMID:022041057</ref><references group="xtra"/>
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[[Category: Sherer, B A]]
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[[Category: Staphylococcus aureus]]
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[[Category: Boriack-Sjodin, P A.]]
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[[Category: Eakin, A E.]]
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[[Category: Read, J.]]
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[[Category: Sherer, B A.]]
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[[Category: Antimicrobial]]
[[Category: Antimicrobial]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]

Current revision

Crystal structure of a topoisomerase ATPase inhibitor

PDB ID 3ttz

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