3uvn
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3uvn is ON HOLD Authors: Zhang, P., Lee, H., Brunzelle, J.S., Couture, J.-F. Description: Crystal structure of WDR5 in complex with the WDR5-intera...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A== | |
| + | <StructureSection load='3uvn' size='340' side='right'caption='[[3uvn]], [[Resolution|resolution]] 1.79Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3uvn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UVN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.792Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uvn OCA], [https://pdbe.org/3uvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uvn RCSB], [https://www.ebi.ac.uk/pdbsum/3uvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uvn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SET1A_HUMAN SET1A_HUMAN] Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.<ref>PMID:12670868</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brunzelle JS]] | ||
| + | [[Category: Couture J-F]] | ||
| + | [[Category: Lee H]] | ||
| + | [[Category: Zhang P]] | ||
Current revision
Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A
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