3t1i

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[[Image:3t1i.png|left|200px]]
 
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==Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations==
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The line below this paragraph, containing "STRUCTURE_3t1i", creates the "Structure Box" on the page.
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<StructureSection load='3t1i' size='340' side='right'caption='[[3t1i]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t1i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T1I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3t1i| PDB=3t1i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t1i OCA], [https://pdbe.org/3t1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t1i RCSB], [https://www.ebi.ac.uk/pdbsum/3t1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t1i ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mre11 plays an important role in repairing damaged DNA by cleaving broken ends and by providing a platform for other DNA repair proteins. Various Mre11 mutations have been identified in several types of cancer. We have determined the crystal structure of the human Mre11 core (hMre11), which contains the nuclease and capping domains. hMre11 dimerizes through the interfaces between loop beta3-alpha3 from one Mre11 and loop beta4-beta5 from another Mre11, and between loop alpha2-beta3 from one Mre11 and helices alpha2 and alpha3 from another Mre11, and assembles into a completely different dimeric architecture compared with bacterial or archaeal Mre11 homologs. Nbs1 binds to the region containing loop alpha2-beta3 which participates in dimerization. The hMre11 structure in conjunction with biochemical analyses reveals that many tumorigenic mutations are primarily associated with Nbs1 binding and partly with nuclease activities, providing a framework for understanding how mutations inactivate Mre11.
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===Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations===
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Crystal structure of human mre11: understanding tumorigenic mutations.,Park YB, Chae J, Kim YC, Cho Y Structure. 2011 Nov 9;19(11):1591-602. PMID:22078559<ref>PMID:22078559</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3t1i" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22078559 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22078559}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3t1i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T1I OCA].
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==Reference==
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<ref group="xtra">PMID:022078559</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chae, J.]]
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[[Category: Large Structures]]
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[[Category: Cho, Y.]]
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[[Category: Chae J]]
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[[Category: Kim, Y.]]
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[[Category: Cho Y]]
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[[Category: Park, Y B.]]
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[[Category: Kim Y]]
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[[Category: Dna repair]]
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[[Category: Park YB]]
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[[Category: Endonuclease]]
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[[Category: Exonuclease]]
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[[Category: Hydrolase]]
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[[Category: Metallophosphatase]]
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[[Category: Mrn complex]]
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[[Category: Nbs1]]
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[[Category: Rad50]]
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Current revision

Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations

PDB ID 3t1i

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