3avs

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[[Image:3avs.png|left|200px]]
 
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==Catalytic fragment of UTX/KDM6A bound with N-oxyalylglycine, and Ni(II)==
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The line below this paragraph, containing "STRUCTURE_3avs", creates the "Structure Box" on the page.
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<StructureSection load='3avs' size='340' side='right'caption='[[3avs]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3avs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AVS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3avs| PDB=3avs | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3avs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avs OCA], [https://pdbe.org/3avs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3avs RCSB], [https://www.ebi.ac.uk/pdbsum/3avs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3avs ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KDM6A_HUMAN KDM6A_HUMAN] Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/KDM6A_HUMAN KDM6A_HUMAN] Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A.<ref>PMID:17851529</ref> <ref>PMID:17761849</ref>
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===Catalytic fragment of UTX/KDM6A bound with N-oxyalylglycine, and Ni(II)===
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==See Also==
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*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22002947 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22002947}}
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==About this Structure==
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[[3avs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVS OCA].
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==Reference==
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<ref group="xtra">PMID:022002947</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Sengoku, T.]]
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[[Category: Large Structures]]
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[[Category: Yokoyama, S.]]
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[[Category: Sengoku T]]
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[[Category: Cupin superfamily]]
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[[Category: Yokoyama S]]
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[[Category: Oxidoreductase]]
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[[Category: Tri/dimethyllysine demethylase]]
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Current revision

Catalytic fragment of UTX/KDM6A bound with N-oxyalylglycine, and Ni(II)

PDB ID 3avs

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