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3t9f

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[[Image:3t9f.png|left|200px]]
 
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==Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PP)2-IP4 (1,5-IP8)==
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The line below this paragraph, containing "STRUCTURE_3t9f", creates the "Structure Box" on the page.
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<StructureSection load='3t9f' size='340' side='right'caption='[[3t9f]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t9f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T9F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=I8P:(1R,3S,4R,5S,6R)-2,4,5,6-TETRAKIS(PHOSPHONOOXY)CYCLOHEXANE-1,3-DIYL+BIS[TRIHYDROGEN+(DIPHOSPHATE)]'>I8P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3t9f| PDB=3t9f | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t9f OCA], [https://pdbe.org/3t9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t9f RCSB], [https://www.ebi.ac.uk/pdbsum/3t9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t9f ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PP)2-IP4 (1,5-IP8)===
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== Function ==
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[https://www.uniprot.org/uniprot/VIP2_HUMAN VIP2_HUMAN] Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.<ref>PMID:17690096</ref> <ref>PMID:17702752</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22119861 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22119861}}
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==About this Structure==
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[[3t9f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T9F OCA].
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==Reference==
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<ref group="xtra">PMID:022119861</ref><references group="xtra"/>
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[[Category: Diphosphoinositol-pentakisphosphate kinase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Falck, J.]]
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[[Category: Large Structures]]
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[[Category: Hall, T M.T.]]
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[[Category: Falck J]]
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[[Category: Shears, S B.]]
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[[Category: Hall TMT]]
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[[Category: Wang, H.]]
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[[Category: Shears SB]]
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[[Category: Atp-grasp fold]]
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[[Category: Wang H]]
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[[Category: Inositol pyrophosphate kinase]]
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[[Category: Phosphoryl transferase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PP)2-IP4 (1,5-IP8)

PDB ID 3t9f

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