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3u82

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'''Unreleased structure'''
 
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The entry 3u82 is ON HOLD until Paper Publication
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==Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion==
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<StructureSection load='3u82' size='340' side='right'caption='[[3u82]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3u82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U82 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.164&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u82 OCA], [https://pdbe.org/3u82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u82 RCSB], [https://www.ebi.ac.uk/pdbsum/3u82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u82 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GD_HHV11 GD_HHV11] Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, PVRL1 and 3-O-sulfated heparan sulfate (By similarity). May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Multiple surface envelope proteins are involved in the human herpes simplex virus type 1 entry and fusion. Among them, glycoprotein D (gD) has an important role by binding to the host receptors such as herpes virus entry mediator and nectin-1. Although the complex structure of gD with herpes virus entry mediator has been established, the binding mode of gD with the nectin-1 is elusive. Nectin-1 is a member of the immunoglobulin (Ig)-like (three Ig-like domains) cell adhesion molecules and is believed to form a homodimer to exert its functions. Here we report the complex structure of gD and nectin-1 (three Ig domains), revealing that gD binds the first Ig domain of nectin-1 in a similar mode to the nectin-1 homodimer interaction. The key amino acids responsible for nectin-1 dimerization are also used for gD/nectin-1 binding. This result indicates that binding of gD to nectin-1 would preclude the nectin-1 dimerization, consequently abolishing its cell adhesion function.
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Authors: Zhang, N., Yan, J., Lu, G., Guo, Z., Fan, Z., Wang, J., Shi, Y., Qi, J., Gao, G.F.
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Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion.,Zhang N, Yan J, Lu G, Guo Z, Fan Z, Wang J, Shi Y, Qi J, Gao GF Nat Commun. 2011 Dec 6;2:577. doi: 10.1038/ncomms1571. PMID:22146396<ref>PMID:22146396</ref>
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Description: Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3u82" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glycoproteins B and D|Glycoproteins B and D]]
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*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human alphaherpesvirus 1 strain 17]]
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[[Category: Large Structures]]
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[[Category: Fan Z]]
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[[Category: Gao GF]]
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[[Category: Guo Z]]
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[[Category: Lu G]]
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[[Category: Qi J]]
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[[Category: Shi Y]]
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[[Category: Wang J]]
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[[Category: Yan J]]
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[[Category: Zhang N]]

Current revision

Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion

PDB ID 3u82

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