3uwn

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'''Unreleased structure'''
 
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The entry 3uwn is ON HOLD
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==The 3-MBT repeat domain of L3MBTL1 in complex with a methyl-lysine mimic==
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<StructureSection load='3uwn' size='340' side='right'caption='[[3uwn]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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Authors: Zhong, N., Tempel, W., Wernimont, A.K., Grslund, S., Ingerman, L.A., Korboukh, V., Kireev, D.B., Gao, C., Frye, S.V., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Brown, P.J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3uwn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWN FirstGlance]. <br>
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Description: The 3-MBT repeat domain of L3MBTL1 in complex with a methyl-lysine mimic
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=UWN:[2-(PHENYLAMINO)BENZENE-1,4-DIYL]BIS{[4-(PYRROLIDIN-1-YL)PIPERIDIN-1-YL]METHANONE}'>UWN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwn OCA], [https://pdbe.org/3uwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwn RCSB], [https://www.ebi.ac.uk/pdbsum/3uwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LMBL1_HUMAN LMBL1_HUMAN] Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.<ref>PMID:17540172</ref> <ref>PMID:18408754</ref> <ref>PMID:20870719</ref> <ref>PMID:20870725</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Brown PJ]]
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[[Category: Edwards AM]]
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[[Category: Frye SV]]
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[[Category: Gao C]]
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[[Category: Graslund S]]
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[[Category: Ingerman LA]]
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[[Category: Kireev DB]]
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[[Category: Korboukh V]]
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[[Category: Tempel W]]
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[[Category: Weigelt J]]
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[[Category: Wernimont AK]]
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[[Category: Zhong N]]

Current revision

The 3-MBT repeat domain of L3MBTL1 in complex with a methyl-lysine mimic

PDB ID 3uwn

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