3uwo
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation== | |
| + | <StructureSection load='3uwo' size='340' side='right'caption='[[3uwo]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3uwo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DJ:3-(1-METHYL-2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)BENZAMIDE'>0DJ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwo OCA], [https://pdbe.org/3uwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwo RCSB], [https://www.ebi.ac.uk/pdbsum/3uwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa PAO1]] | ||
| + | [[Category: Chang J]] | ||
| + | [[Category: Choi JY]] | ||
| + | [[Category: Desbonnet CR]] | ||
| + | [[Category: Dillman K]] | ||
| + | [[Category: Miller AA]] | ||
| + | [[Category: Miller JR]] | ||
| + | [[Category: Plummer MS]] | ||
| + | [[Category: Roush WR]] | ||
| + | [[Category: Soutter HH]] | ||
| + | [[Category: Starr J]] | ||
Current revision
Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation
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