3uwp

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'''Unreleased structure'''
 
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The entry 3uwp is ON HOLD
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==Crystal structure of Dot1l in complex with 5-iodotubercidin==
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<StructureSection load='3uwp' size='340' side='right'caption='[[3uwp]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3uwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5ID:(2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL'>5ID</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwp OCA], [https://pdbe.org/3uwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwp RCSB], [https://www.ebi.ac.uk/pdbsum/3uwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
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Authors: Yu, W., Tempel, W., Smil, D., Schapira, M., Li, Y., Vedadi, M., Nguyen, K.T., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Brown, P.J., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: Crystal structure of Dot1l in complex with 5-iodotubercidin
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Brown PJ]]
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[[Category: Edwards AM]]
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[[Category: Li Y]]
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[[Category: Nguyen KT]]
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[[Category: Schapira M]]
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[[Category: Smil D]]
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[[Category: Tempel W]]
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[[Category: Vedadi M]]
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[[Category: Weigelt J]]
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[[Category: Wernimont AK]]
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[[Category: Yu W]]

Current revision

Crystal structure of Dot1l in complex with 5-iodotubercidin

PDB ID 3uwp

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