3rl7

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[[Image:3rl7.jpg|left|200px]]
 
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==Crystal structure of hDLG1-PDZ1 complexed with APC==
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The line below this paragraph, containing "STRUCTURE_3rl7", creates the "Structure Box" on the page.
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<StructureSection load='3rl7' size='340' side='right'caption='[[3rl7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rl7]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RL7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rl7 OCA], [https://pdbe.org/3rl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rl7 RCSB], [https://www.ebi.ac.uk/pdbsum/3rl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rl7 ProSAT]</span></td></tr>
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{{STRUCTURE_3rl7| PDB=3rl7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DLG1_HUMAN DLG1_HUMAN] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.<ref>PMID:10656683</ref> <ref>PMID:12445884</ref> <ref>PMID:14699157</ref> <ref>PMID:15263016</ref> <ref>PMID:19213956</ref> <ref>PMID:20605917</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The human Discs Large 1 (DLG1) protein uses two of its three PDZ domains to interact with the C-terminal peptide of the Adenomatous Polyposis Coli (APC) tumor suppressor protein. The DLG1/APC complex inhibits the cell cycle progression from the G0/G1 to the S phase, regulates epithelial cell migration and morphogenesis, and is required for polarization of the microtubule cytoskeleton. However, the molecular details of how DLG1 recognizes APC is not clear. In this study, we performed biochemical and biophysical assays to investigate the interactions between PDZ domains of DLG1 and the C-terminal peptide of APC. In addition, we determined the crystal structures of the PDZ1 and PDZ2 domains of DLG1 each in complex with the C-terminal 11-residue peptide of APC. Our biochemical, biophysical, and structural results revealed structural elements and residues on PDZ1 and PDZ2 domains of DLG1 and on APC crucial for their mutual interaction. In particular, our results show that the beta2/beta3 loops of PDZ1 and PDZ2 play important roles in contributing to the binding affinities between PDZ domains and APC, through interacting with the residues upstream of the canonical PDZ-binding S/T-X-V motif. The results provide new insights into the binding mode of a defined C-terminal segment of APC by the PDZ domains of DLG1.
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===Crytal structure of hDLG1-PDZ1 complexed with APC===
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Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein.,Zhang Z, Li H, Chen L, Lu X, Zhang J, Xu P, Lin K, Wu G PLoS One. 2011;6(8):e23507. Epub 2011 Aug 17. PMID:21858148<ref>PMID:21858148</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rl7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21858148 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21858148}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3rl7]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RL7 OCA].
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==Reference==
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<ref group="xtra">PMID:021858148</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, H.]]
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[[Category: Large Structures]]
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[[Category: Wu, G.]]
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[[Category: Li H]]
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[[Category: Zhang, Z.]]
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[[Category: Wu G]]
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[[Category: Membrane protein-signaling protein complex]]
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[[Category: Zhang Z]]
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[[Category: Pdz-ligand complex]]
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Current revision

Crystal structure of hDLG1-PDZ1 complexed with APC

PDB ID 3rl7

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