2l7f
From Proteopedia
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| - | [[Image:2l7f.jpg|left|200px]] | ||
| - | + | ==Solution Structure of the Pitx2 Homeodomain== | |
| - | + | <StructureSection load='2l7f' size='340' side='right'caption='[[2l7f]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2l7f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L7F FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l7f OCA], [https://pdbe.org/2l7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l7f RCSB], [https://www.ebi.ac.uk/pdbsum/2l7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l7f ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Disease == | |
| - | + | [https://www.uniprot.org/uniprot/PITX2_HUMAN PITX2_HUMAN] Peters anomaly;Axenfeld anomaly;Rieger anomaly;Ring dermoid of cornea;Axenfeld-Rieger syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/PITX2_HUMAN PITX2_HUMAN] Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity). | |
| - | == | + | __TOC__ |
| - | [[2l7f]] is a 1 chain structure with sequence from [ | + | </StructureSection> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Baird-Titus | + | [[Category: Large Structures]] |
| - | [[Category: Doerdelmann | + | [[Category: Baird-Titus JM]] |
| - | [[Category: Kojetin | + | [[Category: Doerdelmann T]] |
| - | [[Category: Rance | + | [[Category: Kojetin DJ]] |
| - | + | [[Category: Rance M]] | |
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Current revision
Solution Structure of the Pitx2 Homeodomain
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