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3u7e
From Proteopedia
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| - | [[Image:3u7e.jpg|left|200px]] | ||
| - | + | ==Crystal structure of mPNKP catalytic fragment (D170A)== | |
| - | + | <StructureSection load='3u7e' size='340' side='right'caption='[[3u7e]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3u7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U7E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7e OCA], [https://pdbe.org/3u7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u7e RCSB], [https://www.ebi.ac.uk/pdbsum/3u7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7e ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/PNKP_MOUSE PNKP_MOUSE] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. | |
| - | + | __TOC__ | |
| - | == | + | </StructureSection> |
| - | [[3u7e]] is a 1 chain structure with sequence from [ | + | [[Category: Large Structures]] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Bernstein | + | [[Category: Bernstein N]] |
| - | [[Category: Coquelle | + | [[Category: Coquelle N]] |
| - | [[Category: Glover | + | [[Category: Glover JNM]] |
| - | [[Category: Green | + | [[Category: Green R]] |
| - | [[Category: Havali | + | [[Category: Havali Z]] |
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Current revision
Crystal structure of mPNKP catalytic fragment (D170A)
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