3uvm

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[[Image:3uvm.jpg|left|200px]]
 
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==Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4==
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The line below this paragraph, containing "STRUCTURE_3uvm", creates the "Structure Box" on the page.
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<StructureSection load='3uvm' size='340' side='right'caption='[[3uvm]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3uvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UVM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uvm OCA], [https://pdbe.org/3uvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uvm RCSB], [https://www.ebi.ac.uk/pdbsum/3uvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uvm ProSAT]</span></td></tr>
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{{STRUCTURE_3uvm| PDB=3uvm | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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===Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4===
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3uvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVM OCA].
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__TOC__
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[[Category: Histone-lysine N-methyltransferase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Brunzelle, J S.]]
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[[Category: Large Structures]]
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[[Category: Couture, J F.]]
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[[Category: Brunzelle JS]]
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[[Category: Lee, H.]]
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[[Category: Couture J-F]]
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[[Category: Zhang, P.]]
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[[Category: Lee H]]
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[[Category: Beta-propeller]]
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[[Category: Zhang P]]
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[[Category: Chromatin biology]]
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[[Category: Histone h3]]
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[[Category: Nucleus]]
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[[Category: Scaffolding]]
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[[Category: Transcription]]
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[[Category: Trithorax]]
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Current revision

Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4

PDB ID 3uvm

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