3uvn

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[[Image:3uvn.jpg|left|200px]]
 
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==Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A==
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The line below this paragraph, containing "STRUCTURE_3uvn", creates the "Structure Box" on the page.
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<StructureSection load='3uvn' size='340' side='right'caption='[[3uvn]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3uvn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UVN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.792&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uvn OCA], [https://pdbe.org/3uvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uvn RCSB], [https://www.ebi.ac.uk/pdbsum/3uvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uvn ProSAT]</span></td></tr>
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{{STRUCTURE_3uvn| PDB=3uvn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SET1A_HUMAN SET1A_HUMAN] Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.<ref>PMID:12670868</ref>
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===Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A===
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3uvn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVN OCA].
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__TOC__
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[[Category: Histone-lysine N-methyltransferase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Brunzelle, J S.]]
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[[Category: Large Structures]]
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[[Category: Couture, J F.]]
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[[Category: Brunzelle JS]]
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[[Category: Lee, H.]]
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[[Category: Couture J-F]]
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[[Category: Zhang, P.]]
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[[Category: Lee H]]
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[[Category: Beta-propeller]]
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[[Category: Zhang P]]
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[[Category: Chromatin biology]]
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[[Category: Histone h3]]
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[[Category: Nucleus]]
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[[Category: Scaffolding]]
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[[Category: Transcription]]
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[[Category: Trithorax]]
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Current revision

Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A

PDB ID 3uvn

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