Response regulator

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{{STRUCTURE_1zg1| PDB=1zg1 | SIZE=400| SCENE= |right|CAPTION=Se-Met ''E. coli'' response regulator NarL complex with DNA and sulfate, [[1zg1]] }}
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<StructureSection load='1kgs' size='350' side='right' scene='' caption='Se-Met DNA-binding response regulator D complex with thiocyanate, [[1kgs]]'>
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'''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments.
'''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments.
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Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. RR CheY is a chemotaxis response regulator in bacteria. RR Spo0 is the sporulation response regulator. Details on response regulator PleD see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]]. For details on PhoP see [[PhoP Regulatory Domain]] and [[PhoP-PhoQ]].
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Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain (DBD).
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*'''RR CheY''' is a chemotaxis response regulator in bacteria see [[Chemotaxis protein]].<ref>PMID:14563873</ref>. <br />
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*'''RR Spo0''' is the sporulation response regulator<ref>PMID:12829280</ref>. <br />
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*'''RR PleD''' is required in loss of motility<ref>PMID:7592388</ref>. For details see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]] and [[Response regulator PLED in complex with C-di-GMP]]<br />
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*'''RR PhoP''' is important for survival under conditions of macrophage-induced stress<ref>PMID:21634789</ref>. For details see [[PhoP Regulatory Domain]] and [[PhoP-PhoQ]]<br />
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*'''Photosynthetic apparatus RR''' in ''Rhodobacter sphaeroides'' is involved in the transduction of signals which monitor oxygen levels. <ref>PMID:8955382</ref>. For details see [[PrrA in Rhodobacter sphaeroides]] <br />
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*'''RR WspR''' couples the chemosensory Wsp pathway to the overproduction of acetylated cellulase <ref>PMID:17379708</ref>. For details see [[WspR]].<br />
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*'''Redox RR''' is DNA-sequence specific. It controls transcription as a result of its phosphorylation by a redox sensor<ref>PMID:8405457</ref>. <br />
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{{TOC limit|limit=2}}
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For '''iron response regulator Irr''' see [[Irr]].
== 3D Structures of response regulator ==
== 3D Structures of response regulator ==
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[[Response regulator 3D structure]]
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''Updated December 2011''
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</StructureSection>
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[[3sft]] – TmCheB methyltransferase catalytic domain – ''Thermotoga maritima''<br />
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[[1u0s]] – TmCheA + CheY<br />
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[[1p2f]] – TmDrrB<br />
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[[1kgs]] - TmDrrD<br />
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[[3gl9]], [[3dgf]] – TmRR<br />
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[[3snk]] – CheY-like – ''Mesorhizobium loti''<br />
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[[1fc3]], [[1dz3]], [[1qmp]] – BsSpo0A - ''Bacillus subtilis''<br />
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[3crn]], [[3cg4]] - CheY-like – ''Methanospirillum hungatei''<br />
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[[1ixm]] – BsSpo0B<br />
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[[1nat]] – BsSPo0F<br />
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[[1srr]] - BsSPo0F (mutant) <br />
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[[3p3q]] – McMmoQ (mutant) – ''Methylococcus capsulatus''<br />
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[[3ljx]] – McMmoQ residues 20-298<br />
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[[3n0r]] – CvPhyR – ''Caulobacter vibrioides''<br />
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[[1m5t]], [[1m5u]] - CvDivK<br />
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[[3n53]] – RR – ''Pelobacter carbinolicus''<br />
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[[3nhm]] – MxRR – ''Myxococcus xanthus''<br />
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[[3kto]] - RR – ''Pseudoalteromonas atlantica''<br />
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[[3f7a]], [[3eq2]] – PaRssB – ''Pseudomonas aeruginosa''<br />
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[[3es2]] – PaRssB phosphatase domain<br />
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[[3i5b]] – PaWpsR GGDEF domain<br />
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[[3i5c]] - PaWpsR GGDEF domain/GCN4 leucine zipper<br />
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[[1yio]], [[1zn2]] – PfStyR – ''Pseudomonas fluorescens''<br />
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[[3hdv]] – RR – ''Pseudomonas putida''<br />
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[[3i5a]] – WpsR – ''Pseudomonas syringae''<br />
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[[3heb]] – CheY – ''Rhodospirillum rubrum''<br />
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[[3eqz]] – CpRR – ''Colwellia psychrerythraea''<br />
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[[2zay]] – RR residues 150-285 – ''Desulfuromonas acetoxidans''<br />
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[[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br />
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[[1xhe]] – EcArcA (mutant) - ''Escherichia coli''<br />
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[[1jbe]] - EcCheY<br />
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[[1mih]] - EcCheY (mutant)<br />
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[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpRR MICA receiver domain<br />
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[[2gwr]] – MtMtrA - ''Mycobacterium tuberculosis''<br />
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[[3c3w]] – MtDosR <br />
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[[2y79]] – MtDooS GAP domain (mutant)<br />
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[[1ys6]] – MtPrrA<br />
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[[1k66]] – ToRcpB – ''Tolypothrix''<br />
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[[1k68]] – ToRcpA<br />
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[[3p01]] – RR residues 134-315 – ''Nostoc''<br />
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[[3ilh]] – RR – ''Cytophaga hutchinsonii''<br />
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[[2qvg]] – RR – ''Legionella pneumophila''<br />
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[[2qr3]] – RR – ''Bacterioides fragilis''<br />
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[[2chy]] – CheY – ''Salmonella typhimurium''
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===Response regulator signal receiving domain===
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[[2qxy]] – TmRR <br />
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[[3i42]] - CheY-like – ''Methylobacillus flagellatus''<br />
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[[2zwm]]– BsYycF <br />
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[[1mvo]] - BsPhoP <br />
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[[2pkx]] - EcPhoP <br />
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[[3gkg]], [[2i6f]] – MxFrzS <br />
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[[2nt3]], [[2nt4]] - MxFrzS (mutant) <br />
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[[3lte]] – RR – ''Bermanella marisrubri''<br />
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[[3hv2]] – PfRR <br />
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[[3kht]] – RR – ''Hahella chejuensis''<br />
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[[3jte]] – CtRR - ''Clostridium thermocellum''<br />
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[[3cnb]] – CpRR <br />
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[[3c3m]] – RR – ''Methanoculleus marisnigri''<br />
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[[2qsj]] – LuxR – ''Silicibacter pomeroyi''<br />
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[[2pln]] – RR – ''Helicobacter pylori''<br />
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[[2jb9]], [[2jba]] – EcPhoB (mutant) <br />
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[[3lua]] – CtRR<br />
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[[3lsg]] – YesN – ''Fusobacterium nucleatum''<br />
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[[3cz5]] – LuxR – ''Aurantimonas''<br />
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[[2qzj]] – RR – ''Clostridium difficile''<br />
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[[1a04]], [[1rnl]] – EcNarL
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===Response regulator DNA-binding domain===
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[[2zxj]] - SaYycF - ''Staphylococcus aureus''<br />
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[[2rnj]] - SaVraR - NMR<BR />
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[[2hwv]] – VicR – ''Enterococcus faecalis''<br />
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[[1umq]] – PrrA – ''Rhodobacter sphaeroides'' – NMR<BR />
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[[3c57]] – MtDosR <br />
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[[3zxo]] – MtDosS<br />
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[[3zxq]] – MtDosT<br />
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[[2pmu]] – MtPhoP<br />
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[[1irz]] – Arr10-B – ''Arabidopsis thaliana'' - NMR
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===Response regulator complex===
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[[3nnn]] – TmDrrD signal receiving domain + BeF3<br />
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[[3nns]] – TmDrrB signal receiving domain + BeF3<br />
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[[3a0u]] - TmTrrA + Mg + BeF3<br />
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[[3a10]] - TmTrrA (mutant) + Mg + BeF3<br />
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[[3rqi]] – RR + phosphorylated aspartic acid + citrate + Ca – ''Burkholderia pseudomallei''<br />
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[[3q15]] – BsRapH + sporulation initiation phosphotransferase <br />
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[[3m6m]] – RpfF residues 400-541 + RpfF protein REC domain – ''Xanthomonas campestris''<br />
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[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + metal ion<br />
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[[2wb4]] – PleD + cyclic diguanosine monophosphate + BeF3 – ''Caulobacter crescentus''<br />
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[[2v0n]] – CvPleD residues 2-454 + cyclic diguanosine monophosphate + GTP + BeF3<br />
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[[3hzh]] – CheX + CheY + Mg + BeF3 – ''Borrelia burgdorferi''<br />
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[[1xhf]] - EcArcA (mutant) + BeF3<br />
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[[2a9o]], [[2a9p]], [[2a9q]], [[2a9r]] – SpYycF + BeF3 – ''Streptococcus pneumoniae''<br />
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[[1ys7]] – MtPrrA + Mg<br />
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[[1jlk]], [[1i3c]] – Rcp1 + Mn]] - ''Synechocystis''<br />
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[[3dge]] – TmRR + SP cytoplasmic domain<br />
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[[3a0r]] – TmTrrA + histidine kinase ThkA<br />
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[[1zg1]], [[1zg5]], [[1je8]] – EcNarL DNA-binding domain + DNA<br />
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[[1p6q]] – SmChey2 + Mg – ''Sinorhizobium meliloti'' – NMR<br />
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[[1p6u]] – SmChey2 + Mg + BeF3 – NMR
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Se-Met DNA-binding response regulator D complex with thiocyanate, 1kgs

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References

  1. ↑ Smith JG, Latiolais JA, Guanga GP, Citineni S, Silversmith RE, Bourret RB. Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY. J Bacteriol. 2003 Nov;185(21):6385-91. PMID:14563873
  2. ↑ Ladds JC, Muchova K, Blaskovic D, Lewis RJ, Brannigan JA, Wilkinson AJ, Barak I. The response regulator Spo0A from Bacillus subtilis is efficiently phosphorylated in Escherichia coli. FEMS Microbiol Lett. 2003 Jun 27;223(2):153-7. PMID:12829280
  3. ↑ Hecht GB, Newton A. Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. J Bacteriol. 1995 Nov;177(21):6223-9. PMID:7592388
  4. ↑ Menon S, Wang S. Structure of the Response Regulator PhoP from Mycobacterium tuberculosis Reveals a Dimer through the Receiver Domain. Biochemistry. 2011 Jul 5;50(26):5948-57. Epub 2011 Jun 13. PMID:21634789 doi:10.1021/bi2005575
  5. ↑ Eraso JM, Kaplan S. Complex regulatory activities associated with the histidine kinase PrrB in expression of photosynthesis genes in Rhodobacter sphaeroides 2.4.1. J Bacteriol. 1996 Dec;178(24):7037-46. PMID:8955382
  6. ↑ Malone JG, Williams R, Christen M, Jenal U, Spiers AJ, Rainey PB. The structure-function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domain. Microbiology. 2007 Apr;153(Pt 4):980-94. PMID:17379708 doi:http://dx.doi.org/10.1099/mic.0.2006/002824-0
  7. ↑ Allen JF. Redox control of transcription: sensors, response regulators, activators and repressors. FEBS Lett. 1993 Oct 18;332(3):203-7. PMID:8405457

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