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| - | [[Image:2cmz.gif|left|200px]]<br /><applet load="2cmz" size="350" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[5i2m]] This PDB entry is obsolete and replaced by 5i2m |
| - | caption="2cmz, resolution 2.40Å" />
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| - | '''CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION'''<br />
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| - | ==Overview==
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| - | The vesicular stomatitis virus has an atypical membrane fusion, glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms, at the virus surface. Membrane fusion is triggered during the transition, from the high- to low-pH form. The structure of G in its low-pH form shows, the classic hairpin conformation observed in all other fusion proteins in, their postfusion conformation, in spite of a novel fold combining features, of fusion proteins from classes I and II. The structure provides a, framework for understanding the reversibility of the G conformational, change. Unexpectedly, G is homologous to gB of herpesviruses, which raises, important questions on viral evolution.
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| - | ==About this Structure==
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| - | 2CMZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=PE4:'>PE4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMZ OCA].
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| - | ==Reference==
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| - | Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G., Roche S, Bressanelli S, Rey FA, Gaudin Y, Science. 2006 Jul 14;313(5784):187-91. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16840692 16840692]
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| - | [[Category: Single protein]]
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| - | [[Category: Vesicular stomatitis indiana virus]]
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| - | [[Category: Bressanelli, S.]]
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| - | [[Category: Roche, S.]]
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| - | [[Category: CA]]
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| - | [[Category: PE4]]
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| - | [[Category: envelope protein]]
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| - | [[Category: glycoprotein]]
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| - | [[Category: lipoprotein]]
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| - | [[Category: membrane]]
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| - | [[Category: membrane protein]]
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| - | [[Category: transmembrane]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:37:06 2008''
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