2etx

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[[Image:2etx.png|left|200px]]
 
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==Crystal Structure of MDC1 Tandem BRCT Domains==
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The line below this paragraph, containing "STRUCTURE_2etx", creates the "Structure Box" on the page.
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<StructureSection load='2etx' size='340' side='right'caption='[[2etx]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2etx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ETX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ETX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.33&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2etx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2etx OCA], [https://pdbe.org/2etx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2etx RCSB], [https://www.ebi.ac.uk/pdbsum/2etx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2etx ProSAT]</span></td></tr>
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{{STRUCTURE_2etx| PDB=2etx | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of MDC1 Tandem BRCT Domains===
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[https://www.uniprot.org/uniprot/MDC1_HUMAN MDC1_HUMAN] Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.<ref>PMID:14695167</ref> <ref>PMID:12475977</ref> <ref>PMID:12499369</ref> <ref>PMID:12551934</ref> <ref>PMID:12611903</ref> <ref>PMID:12607003</ref> <ref>PMID:12607004</ref> <ref>PMID:12607005</ref> <ref>PMID:15201865</ref> <ref>PMID:15377652</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_22139841}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 22139841 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/et/2etx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_22139841}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2etx ConSurf].
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[[2etx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ETX OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022139841</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Joachimiak, A.]]
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[[Category: Large Structures]]
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[[Category: Kim, Y.]]
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[[Category: Joachimiak A]]
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[[Category: Mer, G.]]
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[[Category: Kim Y]]
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[[Category: Thompson, J R.]]
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[[Category: Mer G]]
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[[Category: Wasielewski, E.]]
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[[Category: Thompson JR]]
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[[Category: Cell cycle]]
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[[Category: Wasielewski E]]
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[[Category: Tandem brct domains histone gamma-h2ax]]
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Current revision

Crystal Structure of MDC1 Tandem BRCT Domains

PDB ID 2etx

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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