1b7f

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[[Image:1b7f.png|left|200px]]
 
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==SXL-LETHAL PROTEIN/RNA COMPLEX==
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The line below this paragraph, containing "STRUCTURE_1b7f", creates the "Structure Box" on the page.
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<StructureSection load='1b7f' size='340' side='right'caption='[[1b7f]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1b7f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B7F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b7f OCA], [https://pdbe.org/1b7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b7f RCSB], [https://www.ebi.ac.uk/pdbsum/1b7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b7f ProSAT], [https://www.topsan.org/Proteins/RSGI/1b7f TOPSAN]</span></td></tr>
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{{STRUCTURE_1b7f| PDB=1b7f | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SXL_DROME SXL_DROME] Sex determination switch protein which controls sexual development by sex-specific splicing. Regulates dosage compensation in females by suppressing hyperactivation of X-linked genes. Expression of the embryo-specific isoform is under the control of primary sex-determining signal, which depends on the ratio of X chromosomes relative to autosomes (X:A ratio). Expression occurs in 2X:2A cells, but not in X:2A cells. The X:A ratio seems to be signaled by the relative concentration of the X-linked transcription factors SIS-A and SIS-B. As a result, the embryo-specific product is expressed early only in female embryos and specifies female-adult specific splicing; in the male where it is not expressed, the default splicing gives rise to a truncated non-functional protein. The female-specific isoform specifies the splicing of its own transcript, thereby initiating a positive autoregulatory feedback loop leading to female development pathway. The female-specific isoform controls the sex-specific splicing of transformer (TRA); acts as a translational repressor for male-specific lethal-2 (MSL-2) and prevents male-less (MLE), MSL-1 and MSL-3 proteins from associating with the female X chromosome.<ref>PMID:3144435</ref> <ref>PMID:1710769</ref> <ref>PMID:1547493</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/1b7f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b7f ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Sex-lethal (Sxl) protein of Drosophila melanogaster regulates alternative splicing of the transformer (tra) messenger RNA precursor by binding to the tra polypyrimidine tract during the sex-determination process. The crystal structure has now been determined at 2.6 A resolution of the complex formed between two tandemly arranged RNA-binding domains of the Sxl protein and a 12-nucleotide, single-stranded RNA derived from the tra polypyrimidine tract. The two RNA-binding domains have their beta-sheet platforms facing each other to form a V-shaped cleft. The RNA is characteristically extended and bound in this cleft, where the UGUUUUUUU sequence is specifically recognized by the protein. This structure offers the first insight, to our knowledge, into how a protein binds specifically to a cognate RNA without any intramolecular base-pairing.
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===SXL-LETHAL PROTEIN/RNA COMPLEX===
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Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein.,Handa N, Nureki O, Kurimoto K, Kim I, Sakamoto H, Shimura Y, Muto Y, Yokoyama S Nature. 1999 Apr 15;398(6728):579-85. PMID:10217141<ref>PMID:10217141</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10217141}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1b7f" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10217141 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10217141}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1b7f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B7F OCA].
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==Reference==
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<ref group="xtra">PMID:010217141</ref><ref group="xtra">PMID:014636602</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Handa, N.]]
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[[Category: Large Structures]]
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[[Category: Kim, I.]]
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[[Category: Handa N]]
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[[Category: Kurimoto, K.]]
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[[Category: Kim I]]
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[[Category: Muto, Y.]]
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[[Category: Kurimoto K]]
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[[Category: Nureki, O.]]
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[[Category: Muto Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Nureki O]]
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[[Category: Sakamoto, H.]]
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[[Category: Sakamoto H]]
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[[Category: Shimura, Y.]]
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[[Category: Shimura Y]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rna complex]]
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[[Category: Rna-binding protein-rna complex]]
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[[Category: Rnp domain]]
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[[Category: Rsgi]]
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[[Category: Splicing regulation]]
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[[Category: Structural genomic]]
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Current revision

SXL-LETHAL PROTEIN/RNA COMPLEX

PDB ID 1b7f

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