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2kn4

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[[Image:2kn4.png|left|200px]]
 
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==The structure of the RRM domain of SC35==
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The line below this paragraph, containing "STRUCTURE_2kn4", creates the "Structure Box" on the page.
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<StructureSection load='2kn4' size='340' side='right'caption='[[2kn4]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kn4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_sp._'group_G' Streptococcus sp. 'group G']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KN4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kn4 OCA], [https://pdbe.org/2kn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kn4 RCSB], [https://www.ebi.ac.uk/pdbsum/2kn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kn4 ProSAT]</span></td></tr>
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{{STRUCTURE_2kn4| PDB=2kn4 | SCENE= }}
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</table>
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== Function ==
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===The structure of the RRM domain of SC35===
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[https://www.uniprot.org/uniprot/SRSF2_HUMAN SRSF2_HUMAN] Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.<ref>PMID:19592491</ref> <ref>PMID:21157427</ref> [https://www.uniprot.org/uniprot/SPG2_STRSG SPG2_STRSG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 22140111 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kn/2kn4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_22140111}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kn4 ConSurf].
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[[2kn4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp._group_g,_homo_sapiens Streptococcus sp. group g, homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KN4 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:022140111</ref><references group="xtra"/>
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__TOC__
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[[Category: Streptococcus sp. group g, homo sapiens]]
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</StructureSection>
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[[Category: Clayton, J C.]]
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[[Category: Homo sapiens]]
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[[Category: Goult, B T.]]
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[[Category: Large Structures]]
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[[Category: Lian, L Y.]]
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[[Category: Streptococcus sp. 'group G']]
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[[Category: Cell wall]]
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[[Category: Clayton JC]]
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[[Category: Igg-binding protein]]
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[[Category: Goult BT]]
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[[Category: Mrna processing]]
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[[Category: Lian L-Y]]
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[[Category: Mrna splicing]]
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[[Category: Nucleus]]
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[[Category: Peptidoglycan-anchor]]
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[[Category: Phosphoprotein]]
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[[Category: Rna binding protein]]
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[[Category: Rna-binding]]
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[[Category: Rrm domain]]
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[[Category: Secreted]]
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Current revision

The structure of the RRM domain of SC35

PDB ID 2kn4

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