3qbz

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[[Image:3qbz.png|left|200px]]
 
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==Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4==
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The line below this paragraph, containing "STRUCTURE_3qbz", creates the "Structure Box" on the page.
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<StructureSection load='3qbz' size='340' side='right'caption='[[3qbz]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qbz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QBZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.692&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3qbz| PDB=3qbz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qbz OCA], [https://pdbe.org/3qbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qbz RCSB], [https://www.ebi.ac.uk/pdbsum/3qbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qbz ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4===
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== Function ==
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[https://www.uniprot.org/uniprot/DBF4_YEAST DBF4_YEAST] Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK has also postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.<ref>PMID:8066465</ref> <ref>PMID:12441400</ref> <ref>PMID:16319063</ref> <ref>PMID:17018296</ref> <ref>PMID:19013276</ref> <ref>PMID:18245450</ref> <ref>PMID:19692334</ref> <ref>PMID:19478884</ref> <ref>PMID:20436286</ref> <ref>PMID:21036905</ref> <ref>PMID:20170732</ref> <ref>PMID:20054399</ref>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22130670}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22130670 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22130670}}
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==About this Structure==
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[[3qbz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QBZ OCA].
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==Reference==
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<ref group="xtra">PMID:022130670</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Duncker, B P.]]
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[[Category: Duncker BP]]
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[[Category: Guarne, A.]]
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[[Category: Guarne A]]
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[[Category: Jones, D R.]]
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[[Category: Jones DR]]
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[[Category: Matthews, L A.]]
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[[Category: Matthews LA]]
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[[Category: Prasad, A A.]]
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[[Category: Prasad AA]]
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[[Category: Cell cycle]]
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[[Category: Fha domain]]
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[[Category: Rad53]]
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[[Category: Replication checkpoint]]
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Current revision

Crystal structure of the Rad53-recognition domain of Saccharomyces cerevisiae Dbf4

PDB ID 3qbz

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