1ca6

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[[Image:1ca6.png|left|200px]]
 
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==INTERCALATION SITE OF HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SSO7D/SAC7D BOUND TO DNA==
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The line below this paragraph, containing "STRUCTURE_1ca6", creates the "Structure Box" on the page.
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<StructureSection load='1ca6' size='340' side='right'caption='[[1ca6]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ca6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CA6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ca6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ca6 OCA], [https://pdbe.org/1ca6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ca6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ca6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ca6 ProSAT]</span></td></tr>
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{{STRUCTURE_1ca6| PDB=1ca6 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DN7D_SULAC DN7D_SULAC] Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature.[UniProtKB:P61990]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sso7d and Sac7d are two small chromatin proteins from the hyperthermophilic archaeabacterium Sulfolobus solfataricus and Sulfolobus acidocaldarius, respectively. The crystal structures of Sso7d-GTGATCGC, Sac7d-GTGATCGC and Sac7d-GTGATCAC have been determined and refined at 1.45 A, 2.2 A and 2.2 A, respectively, to investigate the DNA binding property of Sso7d/Sac7d in the presence of a T-G mismatch base-pair. Detailed structural analysis revealed that the intercalation site includes the T-G mismatch base-pair and Sso7d/Sac7d bind to that mismatch base-pair in a manner similar to regular DNA. In the Sso7d-GTGATCGC complex, a new inter-strand hydrogen bond between T2O4 and C14N4 is formed and well-order bridging water molecules are found. The results suggest that the less stable DNA stacking site involving a T-G mismatch may be a preferred site for protein side-chain intercalation.
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===INTERCALATION SITE OF HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SSO7D/SAC7D BOUND TO DNA===
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Crystal structures of the chromosomal proteins Sso7d/Sac7d bound to DNA containing T-G mismatched base-pairs.,Su S, Gao YG, Robinson H, Liaw YC, Edmondson SP, Shriver JW, Wang AH J Mol Biol. 2000 Oct 27;303(3):395-403. PMID:11031116<ref>PMID:11031116</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1ca6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11031116 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11031116}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1ca6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius Sulfolobus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CA6 OCA].
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==Reference==
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<ref group="xtra">PMID:011031116</ref><references group="xtra"/>
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[[Category: Sulfolobus acidocaldarius]]
[[Category: Sulfolobus acidocaldarius]]
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[[Category: Gao, Y G.]]
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[[Category: Synthetic construct]]
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[[Category: Robinson, H.]]
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[[Category: Gao Y-G]]
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[[Category: Shriver, J W.]]
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[[Category: Robinson H]]
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[[Category: Su, S.]]
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[[Category: Shriver JW]]
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[[Category: Wang, A H.J.]]
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[[Category: Su S]]
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[[Category: Chromosomal protein]]
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[[Category: Wang AH-J]]
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[[Category: Dna binding]]
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[[Category: Hyperthermophile]]
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[[Category: Sac7d]]
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[[Category: Sso7d]]
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[[Category: Structural protein-dna complex]]
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Current revision

INTERCALATION SITE OF HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SSO7D/SAC7D BOUND TO DNA

PDB ID 1ca6

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