3sao

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[[Image:3sao.jpg|left|200px]]
 
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==The Siderocalin Ex-FABP functions through dual ligand specificities==
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The line below this paragraph, containing "STRUCTURE_3sao", creates the "Structure Box" on the page.
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<StructureSection load='3sao' size='340' side='right'caption='[[3sao]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sao]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SAO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DBH:2,3-DIHYDROXY-BENZOIC+ACID'>DBH</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NKN:(2R)-2-HYDROXY-3-(PHOSPHONOOXY)PROPYL+TETRADECANOATE'>NKN</scene></td></tr>
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{{STRUCTURE_3sao| PDB=3sao | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sao OCA], [https://pdbe.org/3sao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sao RCSB], [https://www.ebi.ac.uk/pdbsum/3sao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sao ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EXFAB_CHICK EXFAB_CHICK] Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Galline Ex-FABP was identified as another candidate antibacterial, catecholate siderophore binding lipocalin (siderocalin) based on structural parallels with the family archetype, mammalian Siderocalin. Binding assays show that Ex-FABP retains iron in a siderophore-dependent manner in both hypertrophic and dedifferentiated chondrocytes, where Ex-FABP expression is induced after treatment with proinflammatory agents, and specifically binds ferric complexes of enterobactin, parabactin, bacillibactin and, unexpectedly, monoglucosylated enterobactin, which does not bind to Siderocalin. Growth arrest assays functionally confirm the bacteriostatic effect of Ex-FABP in vitro under iron-limiting conditions. The 1.8 A crystal structure of Ex-FABP explains the expanded specificity, but also surprisingly reveals an extended, multi-chambered cavity extending through the protein and encompassing two separate ligand specificities, one for bacterial siderophores (as in Siderocalin) at one end and one specifically binding copurified lysophosphatidic acid, a potent cell signaling molecule, at the other end, suggesting Ex-FABP employs dual functionalities to explain its diverse endogenous activities.
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===The Siderocalin Ex-FABP functions through dual ligand specificities===
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Galline Ex-FABP Is an Antibacterial Siderocalin and a Lysophosphatidic Acid Sensor Functioning through Dual Ligand Specificities.,Correnti C, Clifton MC, Abergel RJ, Allred B, Hoette TM, Ruiz M, Cancedda R, Raymond KN, Descalzi F, Strong RK Structure. 2011 Dec 7;19(12):1796-806. PMID:22153502<ref>PMID:22153502</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3sao" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22153502}}, adds the Publication Abstract to the page
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*[[Siderocalin 3D structures|Siderocalin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22153502 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22153502}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3sao]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAO OCA].
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==Reference==
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<ref group="xtra">PMID:022153502</ref><references group="xtra"/>
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Clifton, M C.]]
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[[Category: Large Structures]]
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[[Category: Correnti, C.]]
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[[Category: Clifton MC]]
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[[Category: Strong, R K.]]
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[[Category: Correnti C]]
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[[Category: Beta-barrel]]
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[[Category: Strong RK]]
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[[Category: Siderophore binding protein]]
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[[Category: Transport protein]]
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The Siderocalin Ex-FABP functions through dual ligand specificities

PDB ID 3sao

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