3t1l

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[[Image:3t1l.jpg|left|200px]]
 
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==Crystal structure of human Galectin-3 in complex with methyl 2-O-acetyl-3-O-toluoyl-beta-D-talopyranoside==
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The line below this paragraph, containing "STRUCTURE_3t1l", creates the "Structure Box" on the page.
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<StructureSection load='3t1l' size='340' side='right'caption='[[3t1l]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3t1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T1L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MQT:METHYL+2-O-ACETYL-3-O-(4-METHYLBENZOYL)-BETA-D-TALOPYRANOSIDE'>MQT</scene></td></tr>
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{{STRUCTURE_3t1l| PDB=3t1l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t1l OCA], [https://pdbe.org/3t1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t1l RCSB], [https://www.ebi.ac.uk/pdbsum/3t1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t1l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref>
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===Crystal structure of human Galectin-3 in complex with methyl 2-O-acetyl-3-O-toluoyl-beta-D-talopyranoside===
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==See Also==
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*[[Galectin 3D structures|Galectin 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22136701 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22136701}}
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==About this Structure==
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[[3t1l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T1L OCA].
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==Reference==
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<ref group="xtra">PMID:022136701</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Blanchard, H.]]
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[[Category: Large Structures]]
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[[Category: Collins, P M.]]
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[[Category: Blanchard H]]
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[[Category: Beta sandwich]]
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[[Category: Collins PM]]
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[[Category: Sugar binding protein-inhibitor complex]]
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Current revision

Crystal structure of human Galectin-3 in complex with methyl 2-O-acetyl-3-O-toluoyl-beta-D-talopyranoside

PDB ID 3t1l

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OCA

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