3atv

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[[Image:3atv.jpg|left|200px]]
 
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==Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state==
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The line below this paragraph, containing "STRUCTURE_3atv", creates the "Structure Box" on the page.
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<StructureSection load='3atv' size='340' side='right'caption='[[3atv]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3atv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ATV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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{{STRUCTURE_3atv| PDB=3atv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3atv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3atv OCA], [https://pdbe.org/3atv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3atv RCSB], [https://www.ebi.ac.uk/pdbsum/3atv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3atv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS71A_HUMAN HS71A_HUMAN] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).<ref>PMID:16537599</ref> <ref>PMID:22528486</ref> <ref>PMID:23973223</ref>
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===Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state===
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21608060 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21608060}}
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==About this Structure==
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[[3atv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATV OCA].
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==Reference==
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<ref group="xtra">PMID:021608060</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arakawa, A.]]
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[[Category: Large Structures]]
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[[Category: Handa, N.]]
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[[Category: Arakawa A]]
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[[Category: Shirouzu, M.]]
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[[Category: Handa N]]
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[[Category: Yokoyama, S.]]
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[[Category: Shirouzu M]]
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[[Category: Adp binding]]
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[[Category: Yokoyama S]]
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[[Category: Atpase]]
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[[Category: Hydrolase]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state

PDB ID 3atv

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OCA

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