3zy7

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[[Image:3zy7.jpg|left|200px]]
 
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==Crystal structure of computationally redesigned gamma-adaptin appendage domain forming a symmetric homodimer==
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The line below this paragraph, containing "STRUCTURE_3zy7", creates the "Structure Box" on the page.
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<StructureSection load='3zy7' size='340' side='right'caption='[[3zy7]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zy7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZY7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.09&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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{{STRUCTURE_3zy7| PDB=3zy7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zy7 OCA], [https://pdbe.org/3zy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zy7 RCSB], [https://www.ebi.ac.uk/pdbsum/3zy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zy7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AP1G1_MOUSE AP1G1_MOUSE] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Computational design of novel protein-protein interfaces is a test of our understanding of protein interactions and has the potential to allow modification of cellular physiology. Methods for designing high-affinity interactions that adopt a predetermined binding mode have proved elusive, suggesting the need for new strategies that simplify the design process. A solvent-exposed backbone on a beta-strand is thought of as "sticky" and beta-strand pairing stabilizes many naturally occurring protein complexes. Here, we computationally redesign a monomeric protein to form a symmetric homodimer by pairing exposed beta-strands to form an intermolecular beta-sheet. A crystal structure of the designed complex closely matches the computational model (rmsd = 1.0 A). This work demonstrates that beta-strand pairing can be used to computationally design new interactions with high accuracy.
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===Crystal structure of computationally redesigned gamma-adaptin appendage domain forming a symmetric homodimer===
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Computational design of a symmetric homodimer using beta-strand assembly.,Stranges PB, Machius M, Miley MJ, Tripathy A, Kuhlman B Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20562-7. Epub 2011 Dec 5. PMID:22143762<ref>PMID:22143762</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zy7" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22143762}}, adds the Publication Abstract to the page
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*[[Adaptin 3D structures|Adaptin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22143762 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22143762}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3zy7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZY7 OCA].
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==Reference==
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<ref group="xtra">PMID:022143762</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Kuhlman, B.]]
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[[Category: Kuhlman B]]
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[[Category: Machius, M.]]
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[[Category: Machius M]]
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[[Category: Miley, M J.]]
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[[Category: Miley MJ]]
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[[Category: Stranges, P B.]]
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[[Category: Stranges PB]]
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[[Category: Tripathy, A.]]
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[[Category: Tripathy A]]
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[[Category: Computational design]]
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[[Category: Endocytosis]]
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[[Category: Protein design]]
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Current revision

Crystal structure of computationally redesigned gamma-adaptin appendage domain forming a symmetric homodimer

PDB ID 3zy7

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